Mining Chemical Libraries for New Antibacterials

Despite the promise of target-based drug discovery ushered in by the genomics era, no mechanistically novel rationally designed antibiotic has reached clinically utility to address the threat of multi-drug resistant bacterial pathogens. Phenotypic screening remains the primary source for new antibacterial compounds, which mainly come from mining various chemical libraries. In this webinar, Carl Balibar (Merck Research Laboratories) discussed screen design, target bias, and hit-prioritization strategies to identify those entities with the greatest opportunity to be developed into the next new antibiotic.
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Have Your Say on China’s Draft Regulation on Chemical Environmental Risk Assessment and Control

ChemLinked

China’s Ministry of Ecology and Environment (MEE) issued the draft Regulation on Chemical Substance Environmental Risk Assessment and Control on 8 Jan. The new regulation represents a complete overhaul of China’s chemical regulatory framework and will have a huge impact on the industry in terms of their compliance obligations. The deadline for public comment is 20 Feb 2019.
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Petrochemicals, Policy, and Public Health

Decades of policy decisions contributed to the shale gas boom and now the petrochemical industry is eyeing the Ohio River Valley region as a production hub for single-use plastics made out of fracked gas, starting with Shell’s massive new ethane cracker in Monaca, Pennsylvania.
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Multivariate Method Development for On-Line Supercritical Fluid Extraction – Supercritical Fluid Chromatography – Mass Spectrometry

Labmanager

On-Line supercritical fluid extraction – supercritical fluid chromatography – mass spectrometry (SFE-SFC-MS) holds with it the promise for more streamlined sample preparation combined with high efficiency separations for myriad applications in food, environmental, forensics, pharmaceutical, and biological sciences. Even so, the wide application base with respect to types of samples and analytes, combined with the multitude of instrumental settings to be optimized, makes method development an initially daunting task.
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More Than an Oil Change: Industrial Lubricants and Electric Vehicles

The move from internal combustion engines (ICE) to battery powered electric vehicles (EV) will not just reduce our reliance on automotive lubricants like motor oil, but also affect the use of industrial lubricants required for manufacturing EVs and other more sustainable propulsion systems.
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