Discriminating insulin analogs with liquid chromatography-mass spectrometry

March 2, 2018

There is currently a half-dozen different insulin analogs on the market. These differ from each other and from natural insulin by just a few amino acids but exhibit markedly different pharmacokinetic and pharmacodynamic properties. Liquid chromatography and mass spectrometry (LC-MS) offers a powerful tool for the sensitive and quantitative detection and discrimination of these highly similar recombinant proteins. This whitepaper reviews the considerations that analytical chemists should take into account when planning to undertake an LC-MS analysis of an insulin analog-containing specimen.

Spotlight

Union Carbide

At Dow, we work together to provide solutions that make a difference. Connecting closely with our customers in more than 160 countries, we offer more than 5,000 products to create competitive advantage while positively impacting the world we live in. We combine world-class expertise, future-focused technologies, and sustainability to solve global challenges in the areas of energy, consumerism, health and nutrition, infrastructure and transportation.

OTHER WHITEPAPERS
news image

Boosting the performance of natural gas sweetening membrane plants

whitePaper | May 1, 2021

The performance of membrane separation processes is mainly driven by the specific separation performance of the membrane modules in addition to smart integration of this separation unit in the overall process design. The setup of membrane modules for polymeric membranes is often based on either flat sheets or hollow fibers. Given the one or the other concept, the implemented membrane material and separation layer thickness defines the maximum performance of the module with a supportive housing design. Thus, the ability to modify intrinsic properties of the polymer and the control of the membrane formation process are key factors to produce a superior membrane product. This is where competencies of a specialty chemicals company, i.e. Evonik, can contribute to unique membrane solutions for the market.

Read More
news image

Monitoring chemical recycling

whitePaper | April 13, 2022

To reach environmental goals regarding climate change and the circular economy, the recycling rate of plastics has to increase considerably over the coming years.

Read More
news image

Ensuring Compliance with ASTM STANDARDS for Mechanical Testing of Plastics and Composites

whitePaper | June 24, 2022

The performance of CFRPs depends on the fiber strength, the filling ratio of the carbon fibers in the resin and the orientation of the carbon fibers. For these reasons, CFPRs exhibit highly anisotropic mechanical behavior. Specialized

Read More
news image

Tech Trends 2022

whitePaper | December 21, 2022

Over the past two years, the world has been reeling from the shock of the pandemic, and we are now collectively trying to navigate to our “next normal.” Those of us on the Tech Trends team believe that this represents the opportunity to engineer a better future—not to just.

Read More
news image

A New Standard in Passive Fire Protection (PFP) Coatings Performance

whitePaper | July 14, 2022

The hydrocarbon industry has strict international testing standards related to the performance of passive fire protective (PFP) coatings for oil and gas platforms, terminals, refineries and other petrochemical facilities.

Read More
news image

Sustainable Polymers

whitePaper | October 21, 2022

Products made from polymers are all around us – from safe and hygienic food and personal care packaging to clothing made of synthetic fibers that protect us from harmful UV rays.

Read More

Spotlight

Union Carbide

At Dow, we work together to provide solutions that make a difference. Connecting closely with our customers in more than 160 countries, we offer more than 5,000 products to create competitive advantage while positively impacting the world we live in. We combine world-class expertise, future-focused technologies, and sustainability to solve global challenges in the areas of energy, consumerism, health and nutrition, infrastructure and transportation.

Events