Discriminating insulin analogs with liquid chromatography-mass spectrometry

March 2, 2018

There is currently a half-dozen different insulin analogs on the market. These differ from each other and from natural insulin by just a few amino acids but exhibit markedly different pharmacokinetic and pharmacodynamic properties. Liquid chromatography and mass spectrometry (LC-MS) offers a powerful tool for the sensitive and quantitative detection and discrimination of these highly similar recombinant proteins. This whitepaper reviews the considerations that analytical chemists should take into account when planning to undertake an LC-MS analysis of an insulin analog-containing specimen.

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CLO2 Remedies

ClO2 Remedies is a BioSecurity Company specializing in customized biodegradable chlorine dioxide (ClO2) solutions. ClO2 is an exceptionally effective and versatile yet low toxicity anti-microbial; that safely solves wide-spectrum contamination challenges better than chemical alternatives.

OTHER WHITEPAPERS
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Olefin Plant -- Naphtha Steam Cracking (NSC) unit optimization solutions

whitePaper | March 11, 2023

This white paper illustrates how the fast response times and excellent repeatability of on-line FT-NIR and other analyzers can be used to provide complete real-time data for the optimization of naphtha steam-cracking furnaces

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Modelling of Environmental Ageing of Polymers and Polymer Composites Modular and Multiscale Methods

whitePaper | January 5, 2022

Service lifetimes of polymers and polymer composites are impacted by environmental ageing.

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The “No-Excuse” Framework to Accelerate the Path to Net-Zero Manufacturing and Value Chains

whitePaper | January 5, 2023

Although the need for climate action is a growing concern for businesses, the move from talk to “noexcuse” action is still hindered by limited access to detailed information on how businesses can operationalize their commitments and address their carbon-emission challenges throughout their operations and supply chains.

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Chemical Logistics Digital connections and positive reactions

whitePaper | April 8, 2020

Digitalization opens the door to a new age for the chemical industry. It paves the way for companies in the industry from material suppliers to solution and service providers. It is the driving force behind development that creates a new level of efficiency and transparency for the industry’s sensitive supply chains.

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Advanced Recycling Pilot Project

whitePaper | January 24, 2022

The Healthcare Plastics Recycling Council (HPRC) is a private technical coalition of industry peers across the healthcare, recycling, and waste management industries seeking to improve recyclability of plastic products and packaging in healthcare,

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Intelligent Automation in Oil & Gas

whitePaper | May 12, 2021

As the new normal unfolds for the oil and gas industry, leaders are focused on harnessing efficiencies in their operations and becoming more agile. Intelligent Automation is offering the industry the opportunity to use the information they have at their fingertips to uncover efficiencies at a rapid pace – allowing them to better monitor their operations and improve business performance quickly.

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Spotlight

CLO2 Remedies

ClO2 Remedies is a BioSecurity Company specializing in customized biodegradable chlorine dioxide (ClO2) solutions. ClO2 is an exceptionally effective and versatile yet low toxicity anti-microbial; that safely solves wide-spectrum contamination challenges better than chemical alternatives.

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