FLUORINE – SYNTHETIC METHODS FOR SELECTIVE INTRODUCTION INTO SMALL MOLECULE DRUGS
April 24, 2019 | (5:30 PM)
USA (United States of America)
This FREE to attend webinar will be presented by Dr John Studley, Scientific Update and is kindly sponsored by Navin Fluorine International. The fluorine atom is now a well-established facet in the architecture of small molecule drugs. In addition to effects on a drug molecules intrinsic physiochemical properties it plays an important role in absorption and metabolism, moderates basicity of neighbouring amine functionality and, through unique stereoelectronic effects, can stabilise binding conformations for key protein interactions. This, coupled with advances in synthetic methodology and scale-up technology, has driven a year on year increase in the number of clinical candidates containing fluorine- a small number of which survive the merciless attrition statistics and become medicines.