Challenging mirror molecules made with stereochemistry destroying reaction
chemistryworld | April 26, 2018
A substitution reaction known for destroying stereochemistry has been converted into a chirality-creating reaction to tackle one of the toughest organic chemistry challenges: making quaternary carbon centares. There is currently no perfect way to make quaternary stereocentres. Most methods rely on using a prochiral substrate a compound like a tri-substituted alkene with well-defined stereochemistry. But making these pro-chiral substrates is a challenge in itself.