Turning uncertainty into good decisions for chemicals, materials, and formulation R&D

Leachable compounds are currently only evaluated on the toxicological risk they pose to the patient. The effects that leachable compounds have on the quality and safety of pharmaceutical drug products, especially protein drug products, is often overlooked. Interactions of reactive leachable compounds with protein drug products can lead to a loss of efficiency, decrease of stability and increased immunogenicity in the patient population at risk. This webinar describes reactive leachable compounds, the scientific basis to predict leachable-protein interactions and a proof of concept.

This webinar highlights the Chemical Library Enumeration tools in MolSoft's ICM-Chemist software The topics covered include: - Enumeration by Markush R-Group - Enumeration by Reaction - Library filtering and linking to source spreadsheet - Multi-Parameter Optimization

To kick off the 2019 New Year, we’ll reflect on a few lessons, still relevant today, from technological progress in the past. Like us, our forbearers faced political, social, and economic challenges, and, like us, they looked to science for solutions. Along the way, they made amazing discoveries but they also hit brick walls. Then, as now, even the most amazing technological discoveries have a habit of requiring long residence times in developmental stages (often awaiting other discoveries) before they emerge as useful (often in surprising applications) which are now simply taken for granted.

Determining the absolute configuration of small molecules is important early in the drug discovery process. The traditional methodology, X-ray analysis, requires a single crystal. Unfortunately, crystallisation of early-stage molecules can be problematic and time consuming.