Targeted protein degradation using small molecules

Learn how Protacs work for targeted protein degradation to widen the spectrum of targetable proteins Targeted protein degradation (TPD) is an emerging drug discovery strategy that allows access to difficult-to-treat diseases. While traditional small-molecule drugs may only allow access to ~20% of the proteome, degradation techniques may open the door to the other 80%. Proteolysis targeting chimeras (Protacs) are an attractive new means of protein degradation, and work catalytically at sub-stoichiometric levels over an extended length of time. These tools have the potential to widen the spectrum of targetable proteins, including proteins that have proven intractable to traditional approaches.
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OTHER ON-DEMAND WEBINARS

Electrochemical Wastewater Refining: Converting Pollutants into Products

Traditionally, wastewater has been viewed as a source of pollution that can damage ecosystems. However, wastewater collection can be a win-win for the environment and businesses, because it contains several valuable elements like nitrogen, carbon, and phosphorus that can be converted and purified into high-purity products like fertilizers
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Improve Investigation of Incidents, Near Hits and Hazards

Environment, health and safety

This webinar will help you improve your root cause analysis. When you attend this presentation, you’ll learn: How a good root cause investigation can build employee support and “buy in” for safety initiatives and improve your EHS culture Key “why” questions that are fundamental to both approaches for determining root cause, whether you're investigating serious incidents, near hits/close calls, or hazards and risks identified through audits or inspections. How to use the results and findings of your investigation processes to the maximum benefit especially for establishing and completing corrective actions (CA) to avoid incidents and accidents in the future.
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Removing Dangerous Chemicals from the Supply Chain

American Apparel & Footwear Association

Apparel and footwear companies are under immense pressure to minimize their effects on the environment and to improve the sustainability of their supply chain. Organizations and consumers are demanding increased transparency about where and how products are manufactured, and what ingredients they contain. Industry programs and organizational stewardship provide companies with guidelines and support the implementation of sustainable chemical management practices. AAFA’s Restricted Substances List provides companies with information related to international regulations and laws that restrict/ban certain chemicals and substances, and the ZDHC (Zero Discharge of Hazardous Chemicals) program is a global cooperation of more than 50 companies that are jointly looking for safe, sustainable chemical management solutions with the goal of complete removal of dangerous chemicals from the textile supply chain. This webinar will discuss the ZDHC program, AAFA’s Restricted Substances List, steps to detox a supply chain, and how to minimize harmful effects to the environment.
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Chemical Process Intensification

MT

Within chemical process development, program timing often dictates making informed decisions with limited process understanding, especially in the early clinical delivery space. To facilitate this, the Merck Process Development Intensification Laboratory is tasked with developing tools and methodologies aimed towards acquisition of deeper, more fundamental process understanding in a resource sparing manner. These chemical process development techniques are centrally focused around data intensification, or more specifically, more efficient data capture, data reduction and data analysis enabled.
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