Processing High Resilient Flexible PU Foams

Despite the promise of target-based drug discovery ushered in by the genomics era, no mechanistically novel rationally designed antibiotic has reached clinically utility to address the threat of multi-drug resistant bacterial pathogens. Phenotypic screening remains the primary source for new antibacterial compounds, which mainly come from mining various chemical libraries. In this webinar, Carl Balibar (Merck Research Laboratories) will discuss screen design, target bias, and hit-prioritization strategies to identify those entities with the greatest opportunity to be developed into the next new antibiotic.

The Gulf Coast spot fuel market houses the majority of the refining capacity in the U.S. It is comprised of several major pipelines and is a hub for exports to domestic and international regions.

It is estimated that approximately 25% of the maintenance budget in process industries is absorbed by field instrumentation. Depending on their service, in-line pH measurements can burden engineers with a very high maintenance demand; not only with the frequent replacement of electrodes but also their cleaning and calibration which can take up to an hour per installation. With the revolutionary Intelligent Sensor Management (ISM) platform, METTLER TOLEDO has launched a breakthrough in pH measurement and maintenance.

Before marketing a new chemical, the manufacturer/importer, in order to meet the various national and international legal requirements, has to submit information in the form of a notification or registration (e.g. phys-chem, toxicological, ecotoxicological data) to support each Government’s risk assessment to determine whether the substance poses an unreasonable risk to the environment and/or human health. Some countries require pre-manufacture/import notification while for many jurisdictions, the chemical notification process is a tiered system requiring subsequent notifications as the annual amount of the imported or manufactured substance increases. Further, there are expanding global initiatives to assess chemicals already in the marketplace and subsequently take action on any chemicals found to be harmful to human health and/or the environment. Government risk management initiatives are investigating the incorporation of informed substitution and alternatives assessment to identify candidates to replace existing toxics.