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PHOTOCATALYTIC FLUORINATION AND FLUOROALKYLATION

July 07, 2020
USA (United States of America)
SHARESHARESHARE
The importance of fluorine in drugs and agrochemicals is widely recognised, however the synthesis of fluorinated compounds- particularly structurally complex molecules- can be challenging. In recent years photochemical fluorination has emerged as a powerful tool for the construction of C-F bonds and formation of C-C bonds with fluorine containing functional groups such as di- and trifluoromethyl and perfluoroalkyl. In general these methods are mild and tolerate a range of functional groups, enabling synthesis of biologically active molecules and facilitating late stage fluorination approaches.