Bringing Sustainable Catalysts to the Fine Chemicals Industry

Technology Networks | December 16, 2019

CPI has collaborated with Professor Kylie Vincent and Dr Holly Reeve at the University of Oxford to support the scale-up of a technology named HydRegen, a novel means of recycling NADH, a critical but very expensive component of many biocatalytic reactions. Biocatalysis provides safer and more sustainable chemical processing by using enzymes in place of metal-based catalysts (which are often toxic) and replacing flammable organic solvents with water. Scaling up production of HydRegen will allow the University of Oxford to evaluate the technology in an industrial setting. Enzyme catalysts produce highly pure chemical products, thus minimising the need for expensive purification. They are therefore of particular interest in the production of pharmaceuticals, flavourings and fragrances. However, a constant feed of the expensive cofactor NADH is a requirement in many biocatalytic reactions and this has hindered industrial adoption of the technology.

Spotlight

The 2018 Nobel Prize in Chemistry was awarded one half to Frances H Arnold for her work on the directed evolution of enzymes, and with the other half jointly to George P Smith and Sir Gregory P Winter for their work on the phage display of peptides and antibodies. This graphic takes a look at the prize-winning research.

Spotlight

The 2018 Nobel Prize in Chemistry was awarded one half to Frances H Arnold for her work on the directed evolution of enzymes, and with the other half jointly to George P Smith and Sir Gregory P Winter for their work on the phage display of peptides and antibodies. This graphic takes a look at the prize-winning research.

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Heating & Cooling Market value worth $1,400 Billion by 2027, Says Global Market Insights Inc.

Global Market Insights Inc. | November 15, 2021

The heating & cooling market revenue is projected to cross USD 1,400 billion by 2027 as reported in the latest study by Global Market Insights Inc. owing to increasing energy consumption along with rising infrastructural spending. The introduction of green building standards along with favorable government reforms & policies to improve sustainable energy mixes will foster the industry landscape. Paradigm shift toward the integration of thermal energy storage technologies along with increasing district heating and cooling demand will accelerate the business expansion. Rising investments in residential infrastructure for the construction of multi-story buildings along with the developing real estate sector will favour the multi-family residential heating and cooling industry dynamics. Refurbishment and expansion of sustainable heating networks in line with the energy efficiency standards will complement the business dynamics. Increasing energy demand along with large & medium-scale investments toward the adoption of sustainable district heating units will boost the business landscape. The district heating segment has observed a substantial development owing to its environmental-friendly and economical nature. The heat delivered from these units is produced in an eco-friendly manner that reduces the effect of GHG emissions, positively encouraging the technology demand. Favourable government policies restricting carbon emissions together with the accelerating adoption of green energy will thrust the industry outlook. Some prime findings of the global heating & cooling market report include The heating & cooling industry is anticipated to grow owing to rising demand for sustainable heating along with rising investments in residential and commercial infrastructures. Ongoing technological developments to deploy enhanced thermal heating & cooling units will positively encourage the business outlook. Eminent players operating across the global heating & cooling market include Siemens, Johnson Controls, Daikin, Engie, Trane, and Haier Group, amongst others. Large-scale renewable integration followed by shifting focus toward the adoption of smart heating units will positively influence the industry scenario. Browse key industry insights spread across 1,175 pages with 2,285 market data tables & 31 figures & charts from the report, "Heating & Cooling Market Forecasts By Category (Heating, Cooling), Application (Industrial, Residential, Service Sector), Industry Analysis Report, Regional Outlook, Application Potential, Competitive Market Share & Forecast, 2021 – 2027," The COVID-19 has hit the world in an exceptional manner and affected the global economy drastically. The pandemic has resulted in lockdowns and curfews across the globe to avoid virus transmission and has further led respective governments to promote social distancing. In addition, the lack of labour and unavailability of raw materials have further resulted in ceased production and disruptions in the supply chain & distribution network. However, proper vaccination programs and beneficiary measures by governing authorities will lead the industry to come back to its normal position. Middle East heating & cooling market is set to gain momentum owing to the rapidly changing technological advancements along with extreme climatic conditions. Growing inclination toward advanced district cooling infrastructure favoured by commissioning of large number of projects across the region will foster the industry dynamics. For, instance, in 2020, Empower connected Avani Palm View Dubai Hotel & Suites an urban project to its cooling network supplying cooling capacity of TR 2,610 connecting 527 hotel & residential units along retail outlets as well as advanced office spaces. Moreover, the rising per capita income coupled with shifting consumer focus toward luxury & smart technological units will positively sway the business outlook. About Global Market Insights Global Market Insights Inc., headquartered in Delaware, U.S., is a global market research and consulting service provider, offering syndicated and custom research reports along with growth consulting services. Our business intelligence and industry research reports offer clients with penetrative insights and actionable market data specially designed and presented to aid strategic decision making. These exhaustive reports are designed via a proprietary research methodology and are available for key industries such as chemicals, advanced materials, technology, renewable energy, and biotechnology.

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CHEMICAL TECHNOLOGY

Scientists develop catalyst to convert ethanol into high-value chemicals and fuels

Phys | November 11, 2020

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CHEMICAL TECHNOLOGY

Vernalis Research - a Fully Owned Subsidiary of HitGen Inc - and Hannibal Innovation Announce the Creation of Dania Therapeutics ApS

Vernalis Research, | November 01, 2021

Vernalis Research (“Vernalis”), a fully owned subsidiary of HitGen Inc., and Hannibal Innovation ApS (“Hannibal”) are pleased to announce the creation of Dania Therapeutics ApS (“Dania”) to discover small molecules inhibitors against new undisclosed oncology targets. Dania’s new discovery program is based on the work from Professor Kristian Helin at University of Copenhagen. Prof. Helin and Dr. Karl Agger, from his laboratory, are the scientific founders of Dania. Under the terms of the agreement, Vernalis will use its expertise in drug discovery to undertake all activities up to lead optimization and invest in Dania. Vernalis has the option to fund further discovery activities until the nomination of a preclinical candidate. The team at Hannibal will run operations for Dania throughout the initial stages of the collaboration. Mike Wood – Managing Director at Vernalis - will join the Board of Dania. Hamed Brodersen and Karin Absalonsen from Hannibal will act as CEO and Chair of the Board of directors, respectively. Kim Andersen joins as COO of Dania. “We are extremely pleased to work with Kristian Helin and Hannibal on such exciting targets. This innovative business model where Vernalis trades the usual cash and milestones payments for equity demonstrates Vernalis’ confidence in its expertise and its ability to collaborate with talented scientists and successful entrepreneurs and we have been impressed by the quality of the work from Kristian and the track record from the team at Hannibal in creating and nurturing successful biotech companies.'' Mike Wood – Managing Director at Vernalis “We are very excited about the creation of Dania, and the collaboration with Hannibal and Vernalis in starting the company,” said Kristian Helin. “We are looking forward to our continued collaboration and the development of new inhibitors to the oncology targets, identified in my lab at University of Copenhagen.” “Hannibal wants to be the go-to partner for scientists and research institutions that stand out in the industry because of the depth and quality of their scientific work. It is an honor for us to work with Kristian Helin in bringing new breakthroughs in science to underserved patients. We are also thrilled to work with Vernalis, which has an excellent track record in structure-based drug discovery, a strong management team and visionary owners. Hannibal’s business model is to establish strong partnerships with innovative approaches to business development. We look forward to shaping the industry together with Kristian and Vernalis,” said Hamed Brodersen, CEO of Hannibal. About HitGen HitGen Inc. is a biotech company headquartered in Chengdu, China, with subsidiaries in Cambridge, UK and Houston, USA. It became a publicly listed company in Shanghai Stock Exchange in April 2020 (ticker code 688222.SH). HitGen has established a drug discovery research platform for small molecules and nucleic acid drug centered on the design, synthesis and screening of DNA encoded chemical libraries (DELs), fragment-based drug discovery (FBDD) and structure-based drug design (SBDD) technologies. HitGen's DELs currently contains more than 1 trillion novel, diverse, drug-like small molecules and macrocyclic compounds. These compounds are members of DELs synthesized from many thousands of distinct chemical scaffolds, designed with tractable chemistry, and have yielded proven results for the discovery of small molecule leads against precedented and unprecedented classes of biological targets. Through its acquisition of Cambridge UK based Vernalis R&D Ltd before the end of 2020, a leader in FBDD/SBDD, HitGen now has a research team of over 500 scientists and offers a full set of research capabilities from recombinant protein expression and purification, structural biology, assay development, screening, DEL synthesis, nucleic acid and small molecule chemical synthesis, computational and medicinal chemistry, biochemistry and biophysics, cell biology, in vivo pharmacology, DMPK, CMC, etc., to enable drug discovery research from target gene to IND filing. About Kristian Helin Kristian Helin is the CEO and President at The Institute of Cancer Research (www.icr.ac.uk) and was formerly Director of the Biotech Research & Innovation Centre, University of Copenhagen and Chair of the Cell Biology Program at Memorial Sloan Kettering Cancer Center. About Hannibal Innovation Hannibal transitions important science and technology into growth companies and provides alternative investment opportunities for long-term investors seeking higher yields. We do it to save lives, impact societies, and make a profit.

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