Article | July 20, 2022
An enzyme-mimicking catalyst opens a new route to important organic molecules such as glycolic acid and amino acids from pyruvate, report researchers in Japan. Moreover, the new catalyst is cheaper, more stable, safer and more environmentally friendly than conventional metal catalysts used in industry, they note, adding that it also displays the high enantioselectivity required by the pharmaceutical industry.
“On top of these advantages, our newly developed organic catalyst system also promotes reactions using pyruvate that aren’t easily achievable using metal catalysts,” says Santanu Mondal, a PhD candidate in the chemistry and chemical bioengineering unit at Okinawa Institute of Science and Technology (OIST) Graduate University, Okinawa, Japan, and lead author of a study recently published in Organic Letters.
“Organic catalysts, in particular, are set to revolutionize the industry and make chemistry more sustainable,” he stresses.
The researchers use an acid and an amine mixture to force the pyruvate to act as an electron donor rather than its usual role as an electron receiver (Figure 1).
Effectively mimicking how enzymes work, the amine binds to the pyruvate to make an intermediate molecule. The organic acid then covers up part of the intermediate molecule while leaving another part that can donate electrons free to react to form a new product.
Currently, the organic catalyst system only works when reacting pyruvate with a specific class of organic molecule called cyclic imines.
So, the researchers now are looking to develop a more-universal catalyst, i.e., one that can speed up reactions between pyruvate and a broad range of organic molecules.
The challenge here is to try to make the electron-donating intermediate stage of pyruvate react with other functional groups such as aldehydes and ketones. However, different catalysts create different intermediates, all with different properties. For example, the enamine intermediate created by the researchers’ new reaction only reacts with cyclic imines. Their hypothesis, currently being investigated, is that creation of other intermediates such as an enolate, if possible, would achieve a broader pyruvate reactivity.
In terms of cost, the researchers note that a palladium catalyst used in similar reactions is 25 times more expensive than their organic acid — which also is made from eco-friendly quinine.
In addition, they believe scale-up of the process for industrial use definitely is possible. However, the researchers caution that the current amine-to-acid-catalyst loading ratio of 1:2 probably would need to be optimized for better results at a larger scale.
Article | August 8, 2022
Recent discoveries in the Guyana-Suriname basin attest to estimates of 10+ Bbbl of oil resources and more than 30 Tcf of gas.1 Like many oil & gas successes, this is a story that begins with early exploration success onshore, followed by a long period of exploration disappointment in coastal to shelf regions offshore, eventually culminating in deepwater success.
Article | July 22, 2021
The market size for polymeric and resin binders in the global printing ink marketwas estimated to be over 1,200,000 MT in 2020, with a CAGR of about five percent. A major driver of this growth comes from the packaging industry, due to increases in consumer spending and online shopping, as well as demand for processed and packaged foods and beverages.
In addition, increased use of water-based inks is promoting market growth, off-setting environmental and health concerns regarding solvent-based inks in addition to strict environmental protection policies. Water-based inks are projected to overtake solvent-based inks due to environmental regulations, the reduction of volatile organic compounds (VOCs) in the pressroom, and improvements in overall print quality.
Ink formulations are complex mixtures, consisting of four basic component classes: pigments, polymeric binder resins, solvents or an aqueous dispersant media, and additives, such as surfactants, waxes, and rheology modifiers that enhance print quality. The purpose of the resin binder is to disperse and carry the ink pigment to the substrate, stabilize the pigment and additives dispersion to prevent settling, and provide print properties such as ink transfer behavior, setting, and drying characteristics. The binder also contributes surface appearance and gloss, strength and flexibility, chemical and solvent resistance, and also rub resistance. Ink binders can be categorized into the following polymer and resin types: acrylics, polyurethanes, polyamides, modified resins, hydrocarbon resins, and modified cellulosics.
Article | April 14, 2020
Downhole fluid build-up coupled with a drop in reservoir pressure can lead to the rapid decline of gas production rates, and can ultimately result in a well ceasing production. While there are many ways to deliquify a well to maximise production, chemical foamers can be incredibly effective and well worth considering. In this blog post, Kevin Lonie shares some of the benefits of using chemical foamers, and provides insights and advice around how best to use them… “Foamers are a much cheaper option than alternative solutions, such as mechanical lifts, and there is very little risk associated with their usage. If a foamer doesn’t work, it won’t make the well worse - so often we see clients giving them a go before opting for more expensive methods, in the hope that they produce the desired results. And we have seen their success over and over again.”