Chemical Technology
Article | August 8, 2022
An enzyme-mimicking catalyst opens a new route to important organic molecules such as glycolic acid and amino acids from pyruvate, report researchers in Japan. Moreover, the new catalyst is cheaper, more stable, safer and more environmentally friendly than conventional metal catalysts used in industry, they note, adding that it also displays the high enantioselectivity required by the pharmaceutical industry.
“On top of these advantages, our newly developed organic catalyst system also promotes reactions using pyruvate that aren’t easily achievable using metal catalysts,” says Santanu Mondal, a PhD candidate in the chemistry and chemical bioengineering unit at Okinawa Institute of Science and Technology (OIST) Graduate University, Okinawa, Japan, and lead author of a study recently published in Organic Letters.
“Organic catalysts, in particular, are set to revolutionize the industry and make chemistry more sustainable,” he stresses.
The researchers use an acid and an amine mixture to force the pyruvate to act as an electron donor rather than its usual role as an electron receiver (Figure 1).
Effectively mimicking how enzymes work, the amine binds to the pyruvate to make an intermediate molecule. The organic acid then covers up part of the intermediate molecule while leaving another part that can donate electrons free to react to form a new product.
Currently, the organic catalyst system only works when reacting pyruvate with a specific class of organic molecule called cyclic imines.
So, the researchers now are looking to develop a more-universal catalyst, i.e., one that can speed up reactions between pyruvate and a broad range of organic molecules.
The challenge here is to try to make the electron-donating intermediate stage of pyruvate react with other functional groups such as aldehydes and ketones. However, different catalysts create different intermediates, all with different properties. For example, the enamine intermediate created by the researchers’ new reaction only reacts with cyclic imines. Their hypothesis, currently being investigated, is that creation of other intermediates such as an enolate, if possible, would achieve a broader pyruvate reactivity.
In terms of cost, the researchers note that a palladium catalyst used in similar reactions is 25 times more expensive than their organic acid — which also is made from eco-friendly quinine.
In addition, they believe scale-up of the process for industrial use definitely is possible. However, the researchers caution that the current amine-to-acid-catalyst loading ratio of 1:2 probably would need to be optimized for better results at a larger scale.
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Chemical Technology
Article | July 14, 2022
NOBODY SHOULD be surprised that the developing world has fallen behind in the battle to reduce greenhouse gas emissions as the region is a long way from recovering from the pandemic.Evidence to this effect emerged last week in comments made by Fatih Birol, executive director of the International Energy Agency (IEA).
“In many emerging and developing economies, emissions are heading upwards while clean energy investments are faltering, creating a dangerous fault line in global efforts to reach climate and sustainable energy goals,” said Birol.
At the current rate, carbon dioxide emissions from developing countries largely in Asia, Africa and Latin America are set to increase by 5bn tonnes/year over the next two decades, according to the IEA, as access to power increases.At present, around 785m people worldwide have no access to electricity. There are also 2.6bn people without access to clean cooking options.
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Chemical Technology
Article | August 2, 2022
Global IoT in Chemical market research report provides the newest industry data and industry future trends. It allows you to identify the products and end users driving Revenue growth and profitability. The IoT in Chemical industry report lists the leading competitors and provides the game-changing strategic analysis of the key factors driving the market. The report includes the forecasts by 2020-2028, analysis by 2014-2019, and discussion of important industry trends, market size, market share predictions and profiles of the top IoT in Chemical industry players.
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Chemical Technology
Article | May 10, 2021
MAY 2021 ///Vol 242 No. 5
FEATURES
Organic Oil Recovery improves productivity of existing reservoirs
A transitional technology producing excellent results in extracting hard-to-reach oil is attracting the attention of many large operators. Ancient, resident microbes are used to liberate large oil deposits in depleted reservoirs, thanks to science uncovered by studying the humble Australian koala.
Roger Findlay, Organic Oil Recovery
It began in almost outlandish fashion, with a scientist’s fascination with the complex digestive system of an Australian marsupial, the koala. Today, it has evolved into a green technology that is helping major producers around the world potentially reach billions of dollars of oil that they feared they could never access or bring to the surface.
As the pressure on the oil and gas industry continues to grow, to find new ways to operate with less impact on the environment, Organic Oil Recovery (OOR) is reducing the need for further exploration. Instead, it is helping producers focus on the reservoirs already in situ to extract even more precious resource—at very low cost—from deep below the ground or seas, across a myriad of jurisdictions and geographies.
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