Curbing the costs of chemical manufacturing

The search for new drug candidates has led pharmaceutical investigators to explore molecular structures of increasing complexity. This requirement is the result of the growing recognition that structural complexity can correlate to desirable drug candidate attributes, including enhanced target binding selectivity  solubility and clinical success rates  Considering that structurally complex molecules demand longer and more elaborate series of consecutive chemical transformations for preparation, development teams striving to elaborate efficient and sustainable processes for their manufacture face substantial challenges.On page 681 of this issue, Smaligo et al.  present an example of expeditious preparation of complex molecular scaffolds using new chemical technology.

Spotlight

RG Chemical Safety

This is the business for Richard Greenwood, Consultant in issues relating to workplace chemical hazards and safety, and workplace trainer. Richard Greenwood has worked in the area of chemical safety and hazards classification for over 20 years. In that time he has worked on interpretation of and compliance with the Occupational Health and Safety and Dangerous Goods (Storage and Handling) Regulations in industries ranging from research and training laboratories to large scale chemical manufacturing plant. He commenced interpretation of the Globally Harmonized System of Classification and Labeling of Chemicals (the GHS) in 2002. Working as a Hazardous Chemicals Consultant he was called upon to provide interpretation of complex regulatory requirements to meet industry product movement timescales.

OTHER ARTICLES
Chemical Management

Developing pre-rig solutions that are greener, safer and more efficient

Article | July 8, 2022

MAY 2021 ///Vol 242 No. 5 FEATURES Developing pre-rig solutions that are greener, safer and more efficient There is an increased focus in the oil and gas sector to look further afield to opportunities presented in deepwater locations. Because of this, finding cost-efficient solutions and overcoming the associated challenges that arise below 1,000 ft will be vital for the success of new activity. Jostein Aleksandersen, Neodrill There is an increased focus in the oil and gas sector to look further afield to opportunities presented in deepwater locations. Because of this, finding cost-efficient solutions and overcoming the associated challenges that arise below 1,000 ft will be vital for the success of new activity. All those currently—and those considering—operating in deepwater fields will have an awareness of the general challenges that are presented at such depths. From considerations relating to vast increases in pressure, to the potential for increased drilling time and days spent offshore, there are several hurdles that follow when operating in what are often challenging well environments. In addition, suitable solutions also must support the industry drive to reduce emissions by offering a more carbon-efficient approach.

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Chemical Technology

Ways Your Chemical Company Can Benefit From Digitization

Article | July 20, 2022

The chemical industry is evolving. The marketing, purchasing, and selling of chemicals are being affected by forces in the market, with digitization unquestionably having the most significant impact. Many of the existing digitizing models have likely already been given some thought and then rejected. Chemical businesses are currently conducting pilot projects or starting to gradually scale up their digital initiatives after moving past the proof-of-concept stage. Although this past year brought many difficulties, it also provided an opportunity to revise and re-evaluate foundations moving forward. The Great Reset, as the World Economic Forum has dubbed this time period, is illuminating how the chemical industry might leverage digital technologies to advance. Whether prompted by governmental requirements or consumer desires, chemical businesses' net-zero ambitions will necessitate new expenditures throughout the whole chemical value chain. As a result, back-office costs must be as efficient as possible to free up money to pay for those investments while keeping a profit. Consumer pull The most essential requirements for the success of a new product are a solid understanding of customer needs and wants, the competitive climate, and the makeup of the market. The primary factors that influence the needs of the consumer are price, timing, and quality. Therefore, companies create ongoing procedures and plans with these three factors in mind to better serve client needs and grow their market share by regularly creating new products. Technology pushes The influence of digital technology is constantly growing. One of the foundational elements of 21st-century sources of growth is data-driven innovation. There are numerous items and procedures in the history of innovation that were the result of an accident or careful forethought. Vast volumes of data, or "big data," are being produced and used as a result of the convergence of numerous phenomena, including the growing migration of socio-economic activities on the Internet and the decline in the cost of data collecting, storage, and processing. Large data sets are becoming an essential resource for the economy, supporting the development of new markets, procedures, and goods while also generating substantial competitive advantages. For example, a billion customers can now access broadband at a reasonable price because of the digital world's supporting infrastructure. In addition, cloud computing and the enormous amount of information processing equipment it needs are developing swiftly, and low-cost connected gadgets are being introduced into every industry. Economic benefits The financial gains that can be realized through digitization are genuine. The new digital technologies and businesses have seen an influx of cash, and the public markets are rewarding early adopters with record values. The effects of digitization are spreading swiftly throughout every business. Digitization is the changing of life and work as a result of new technologies, not only their acceptance. Much like earlier technologies, modern emerging technologies like the cloud and big data quickly become part of businesses' operations. Unknown to many, this is having a much more significant impact on the industry that makes these tools as well as on customers. Digitalization that derives from and includes strategic business objectives can greatly benefit chemical firms. Cost savings of roughly 30 to 40 percent can already be made on average today. Additionally, in certain situations, digitalization aided in improving service quality and affected the bottom line by, for instance, enabling new business models. On average, platform-driven digitization projects pay off after 18 months.

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Chemical Management

Key Trends in the Digital Transformation of the Chemical Industry

Article | July 22, 2021

The chemical business is intricate, with numerous sub-sectors dealing with various challenges. Thus, there are some differences in the sector's main areas of digitalization. For instance, while specialty chemicals with smaller batches but larger profit margins are concerned with improving quality, large factories are concentrated on accelerating throughput speed. To be able to react to quick and repeated changes in demand, supply, and working circumstances, however, every plant must optimize output, reduce waste, improve safety and sustainability, and become more nimble. Therefore, the Industrial Internet of Things (IIoT), artificial intelligence (AI), and cloud computing are expected to be the three most popular applications for digital transformation during the coming two years. Key Trends Production Optimization The first and most valuable use cases of digitalization in chemical plants center on production optimization through improved equipment performance, process automation, remote and predictive monitoring, and simplified maintenance. Chemical factories, which often provide basic chemicals for use as end products in other sectors, have a special responsibility to maintain consistently high product quality. However, doing so can be challenging given the significant variations in raw material supply and quality. In addition, as process engineers can change the mix on the fly in reaction to fluctuations in quality, feedstock, or ambient temperatures, better data and analytics enable finer and more frequent adjustments. Lowering Waste The main advantage of digitally transformed plants so far has been cost reduction. The price volatility of raw materials is a problem for the chemical production sector because customers naturally want constant low prices. Minimizing waste is critical since facilities must contend with rising energy costs. Analytics tools that monitor fluctuating raw material prices aid factories in negotiating the best deals with suppliers and preparing in advance for price spikes. The risk of oversupply is reduced since plants can prepare the proper quantities of various products thanks to more precise demand predictions. Sustainability, Compliance, and Safety The chemical industry is heavily regulated as a result of the quantity of hazardous chemicals and the number of end-use industries that rely on it. Businesses are adopting digital transformation to boost safety awareness, reduce emissions and dangerous flare incidents, and guarantee a transparent and accurate audit trail. Plants that quickly adopt digital solutions for remote monitoring, supply chain visibility, waste reduction, production optimization, raising their safety profile, and opening up new opportunities will profit from higher profits and increased revenue, whereas those that hesitate for too long risk failing in the long run.

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Chemical Technology

Application of Chromatography in Various Industries is Changing the Game!

Article | August 8, 2022

Used to separate and analyze compounds into their various components— chromatography plays a crucial part not just in the food industry but in the realms of drug testing, forensics, and even quality control in our favourite alcoholic drinks as well. Advanced Chromatography is an analytical technique introduced to the world by chromatography instrument companies to separate and analyze individual chemicals from complex compounds. Recent developments in the biotechnology and pharma industries have created a significant surge in the chromatography market. Read on to find out five fascinating facts about the day-to-day applications of chromatography in various industries and why businesses are looking to invest more in OEM chromatography manufacturing. Why are Industry-Decision Makers Adapting to Chromatography? Liquid Chromatography; A Popular Choice in Drug Testing Today, a lot of drug tests use liquid chromatography-mass spectrometry because it is easy to use, widely available, and gives quick results. LC and LC-MS can be done in almost any testing facility, which is different from other methods. It can be run by people with little training, so a testing facility can hire mostly technicians instead of highly trained scientists, who are harder to find. LC-MS is also very accurate, which means that there are fewer false positives. With liquid chromatography, you can get results in about 10 to 30 minutes, which is very fast. This technology is used by many drug testing labs across the country. It is widely used and trusted for testing drug samples and many other things. Businesses associated with the sports industry are leveraging chromatography to effectively and accurately test athletes for doping or performance-enhancing drugs. Use of HPCL in Pharmaceutical Industries Chromatography is used in the medical and pharmaceutical industries to create vaccines. In addition, chromatography can determine which antibodies best neutralize viruses and diseases. Mapp Biopharmaceutical, Inc. used the chromatography technique to develop the experimental immunization Zmapp to counteract the deadly Ebola virus. And it is still being used today to fight the coronavirus. The pharmaceutical industry has gained enormous success by exclusively using HPLC to obtain precise results during drug trials. The results can be used to analyze finished drug products and their ingredients quantitatively and qualitatively during manufacturing. The Detector in Forensic Science Chromatography methods are a well-established, powerful suite of methodologies in forensic science, from drug busts, murders, and robberies, to the identification of a plethora of chemical compounds that may be present in samples from terrorist incidents. Forensics use gas chromatography to help solve crimes. It helps analyze blood and clothing samples, allowing forensic scientists to investigate who and what was present at a crime scene. In particular instances, chromatography can even help forensic scientists pinpoint the exact whereabouts of the alleged perpetrator and victim before the crime happened. It’s an error-free process. Therefore, it is incredibly helpful in court. Additionally, chromatography is extremely handy in arson investigations. Most fires have a virtual cocktail of different substances. Every compound and substance differs in size and weight. Chromatography helps break down these varying compounds and substances to help determine what exactly started the fire. Liquid Chromatography in Food Industry Liquid chromatography plays a vital role in the food industry nowadays. It absolves and permits the selective removal of a wide variety of flavor and non-flavor-active food ingredients. The USDA, along with other countries, has prioritized rigorous testing of processed meat's contents. For example, in 2013, it was found that horsemeat was being sold as beef without anyone noticing. As a result, the food industry decided to change its analytical techniques. Chromatography quickly became the best way to find out what was in processed meats. High-Performance Liquid Chromatography and mass spectrometry were used to ensure that meat labeled beef was actually beef. In addition, it could tell if horse meat was mixed in with the beef, which helped keep people safe. Bio-Rad Fast Acid Analysis Column in Beverage Testing Not just food, many beverage manufacturers also use chromatography to ensure that each bottle of their product is the same. But, again, consistent taste is the main priority. And knowing the exact content of each bottle is the most proactive way to measure things. The Bio-Rad fast acid analysis column has been successfully used by many companies to quantitatively determine vitamin C in juices, fresh drinks, and powdered drinks. Chromatography Market is Opening New Dimensions in Various Businesses Undoubtedly, technological advancement has created a vigorous need for chromatography devices. According to Verified Market Research, growing at a CAGR of 3.4% from 2020 to 2027, the chromatography market is projected to reach USD 4.73 billion by 2027. The chromatography instrumentation market is currently witnessing huge advancements in the design of columns. This is raising the demand for development of better analytical reagents and resins. Increasing collaborations among the existing players, specifically in the Asian market is another propelling factor for this market. Additionally, emergence of green chromatography, increasing usage of chromatography instruments for monoclonal antibody purification, and usage of nanomaterial in chromatography are also fuelling the growth of this market. Plus, increased government funding in research and development activities is further driving the market growth. With various pharmaceutical and biotechnology companies, chemical, food and beverage, and other industries contributing to its market growth, one thing is for sure— the increase in the chromatography system market is here to stay.

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Spotlight

RG Chemical Safety

This is the business for Richard Greenwood, Consultant in issues relating to workplace chemical hazards and safety, and workplace trainer. Richard Greenwood has worked in the area of chemical safety and hazards classification for over 20 years. In that time he has worked on interpretation of and compliance with the Occupational Health and Safety and Dangerous Goods (Storage and Handling) Regulations in industries ranging from research and training laboratories to large scale chemical manufacturing plant. He commenced interpretation of the Globally Harmonized System of Classification and Labeling of Chemicals (the GHS) in 2002. Working as a Hazardous Chemicals Consultant he was called upon to provide interpretation of complex regulatory requirements to meet industry product movement timescales.

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Chemical Technology

With the Acquisition of Agiplast, Arkema Strengthens Its Commitment to the Circular Economy

ARKEMA | May 25, 2021

With the planned acquisition of Agiplast, a leader in the regeneration of high-performance polymers, especially specialty polyamides, and fluoropolymers, Arkema is going to be ready to offer a full service to customers in terms of materials circularity, addressing growing market expectations during this field. This project, which contributes to the sustainable development of the polymer industry, is perfectly in line with Arkema’s sustainable growth strategy. Arkema plans to accumulate Agiplast, a company specialized in the regeneration of high-performance polymers, and its historical partner in recycling operations. the company, with annual sales of around €15 million, operates a plant in Italy and has 32 employees. Agiplast’s strong know-how in mechanical recycling technologies will enable Arkema to supply top-quality recycled polymers to its customers. In October 2019, Arkema, the world leader in bio-based high-performance polymers, had already launched Virtucycle®, an ambitious program with Agiplast aimed toward developing loops for the gathering and regeneration of high-performance polymers while minimizing CO2 emissions. With this acquisition, Arkema is going to be the primary fully integrated high-performance polymer manufacturer offering both bio-based and recycled materials to deal with the challenges of resource scarcity and end-of-life products. This bolt-on acquisition is thus in line with Arkema’s CSR and sustainable growth strategy, and especially the transition to a circular economy. The deal is expected to close in June 2021. About ARKEMA Building on its unique set of experience in materials science, Arkema offers a portfolio of first-class technologies to address the ever-growing demand for new and sustainable materials. With the ambition to become 2024 a pure player in Specialty Materials, the Group is structured into 3 complementary, resilient, and highly innovative segments dedicated to Specialty Materials -Adhesive solutions, Advanced Materials, and Coating Solutions- accounting for a few 82% of Group sales, and a well-positioned and competitive Intermediates segments. Arkema offers cutting-edge technological solutions to satisfy the challenges of, among other things, new energies, access to water, recycling, urbanization, and mobility and fosters a permanent dialogue with all its stakeholders. The Group reported sales of around €8 billion in 2020 and operates in some 55 countries with 20,600 employees worldwide

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Chemical Management

Huntsman Completes the Acquisition of Gabriel Performance Products, Further Expanding its Specialty Chemicals Portfolio

Huntsman | January 20, 2021

Huntsman Corporation (NYSE: HUN) today announced it completed the acquisition of Gabriel Performance Products (Gabriel), a North American specialty chemical manufacturer of specialty additives and epoxy curing agents for the coatings, adhesives, sealants and composite end-markets, from Audax Private Equity. Huntsman paid $250 million, subject to customary closing adjustments, in an all-cash transaction funded from available liquidity. Gabriel had 2019 revenues of approximately $106 million with three manufacturing facilities located in Ashtabula, Ohio, Harrison City, Pennsylvania and Rock Hill, South Carolina. Based on calendar year 2019, the purchase price represents an adjusted EBITDA multiple of approximately 11 times, or approximately 8 times pro forma for synergies. Huntsman Corporation is a publicly traded global manufacturer and marketer of differentiated and specialty chemicals with 2019 revenues of approximately $7 billion. Our chemical products number in the thousands and are sold worldwide to manufacturers serving a broad and diverse range of consumer and industrial end markets. We operate more than 70 manufacturing, R&D and operations facilities in approximately 30 countries and employ approximately 9,000 associates within our four distinct business divisions. Certain information in this release constitutes forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. These statements are based on management's current beliefs and expectations. The forward-looking statements in this release are subject to uncertainty and changes in circumstances and involve risks and uncertainties that may affect the company's operations, markets, products, services, prices and other factors as discussed under the caption "Risk Factors" in the Huntsman companies' filings with the U.S. Securities and Exchange Commission. Significant risks and uncertainties may relate to, but are not limited to, volatile global economic conditions, cyclical and volatile product markets, disruptions in production at manufacturing facilities, reorganization or restructuring of Huntsman's operations, including any delay of, or other negative developments affecting the ability to implement cost reductions, timing of proposed transactions, and manufacturing optimization improvements in Huntsman businesses and realize anticipated cost savings, ability to achieve projected synergies, and other financial, economic, competitive, environmental, political, legal, regulatory and technological factors. The company assumes no obligation to provide revisions to any forward-looking statements should circumstances change, except as otherwise required by applicable laws.

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Raw Materials

Conservation Groups Sue EPA for Failure to Adequately Protect against Oil, Methane Gas Industry

Conservation Groups | January 18, 2021

Two conservation groups have launched a lawsuit to fight the EPA’s “failure to require adequate pollution controls for the oil and methane gas industry” in Chicago and areas of California. The Center for Biological Diversity and the Center for Environmental Health point out that two Canadian provinces require that the oil and methane gas industry install zero emission pneumatic controllers. “There is no reason the EPA cannot adopt this readily available technology,” says Kaya Sugerman with the Center for Environmental Health. The EPA’s guidelines for oil and methane gas production recommend pneumatic controllers that emit volatile organic compounds, when pneumatic controllers that do not emit any of these compounds are in widespread use at production sites and compressor stations in both the US and Canada, the groups argue. “Taking action to increase the use of zero emission controllers has a co-benefit of reducing methane, a dangerous greenhouse gas that is 87 times more damaging for climate change than carbon dioxide,” the groups say. They point out that, according to the EPA’s Greenhouse Gas Inventory, pneumatic controllers are the largest source of methane from the oil industry and the second-largest source of methane from the methane gas industry.

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Chemical Technology

With the Acquisition of Agiplast, Arkema Strengthens Its Commitment to the Circular Economy

ARKEMA | May 25, 2021

With the planned acquisition of Agiplast, a leader in the regeneration of high-performance polymers, especially specialty polyamides, and fluoropolymers, Arkema is going to be ready to offer a full service to customers in terms of materials circularity, addressing growing market expectations during this field. This project, which contributes to the sustainable development of the polymer industry, is perfectly in line with Arkema’s sustainable growth strategy. Arkema plans to accumulate Agiplast, a company specialized in the regeneration of high-performance polymers, and its historical partner in recycling operations. the company, with annual sales of around €15 million, operates a plant in Italy and has 32 employees. Agiplast’s strong know-how in mechanical recycling technologies will enable Arkema to supply top-quality recycled polymers to its customers. In October 2019, Arkema, the world leader in bio-based high-performance polymers, had already launched Virtucycle®, an ambitious program with Agiplast aimed toward developing loops for the gathering and regeneration of high-performance polymers while minimizing CO2 emissions. With this acquisition, Arkema is going to be the primary fully integrated high-performance polymer manufacturer offering both bio-based and recycled materials to deal with the challenges of resource scarcity and end-of-life products. This bolt-on acquisition is thus in line with Arkema’s CSR and sustainable growth strategy, and especially the transition to a circular economy. The deal is expected to close in June 2021. About ARKEMA Building on its unique set of experience in materials science, Arkema offers a portfolio of first-class technologies to address the ever-growing demand for new and sustainable materials. With the ambition to become 2024 a pure player in Specialty Materials, the Group is structured into 3 complementary, resilient, and highly innovative segments dedicated to Specialty Materials -Adhesive solutions, Advanced Materials, and Coating Solutions- accounting for a few 82% of Group sales, and a well-positioned and competitive Intermediates segments. Arkema offers cutting-edge technological solutions to satisfy the challenges of, among other things, new energies, access to water, recycling, urbanization, and mobility and fosters a permanent dialogue with all its stakeholders. The Group reported sales of around €8 billion in 2020 and operates in some 55 countries with 20,600 employees worldwide

Read More

Chemical Management

Huntsman Completes the Acquisition of Gabriel Performance Products, Further Expanding its Specialty Chemicals Portfolio

Huntsman | January 20, 2021

Huntsman Corporation (NYSE: HUN) today announced it completed the acquisition of Gabriel Performance Products (Gabriel), a North American specialty chemical manufacturer of specialty additives and epoxy curing agents for the coatings, adhesives, sealants and composite end-markets, from Audax Private Equity. Huntsman paid $250 million, subject to customary closing adjustments, in an all-cash transaction funded from available liquidity. Gabriel had 2019 revenues of approximately $106 million with three manufacturing facilities located in Ashtabula, Ohio, Harrison City, Pennsylvania and Rock Hill, South Carolina. Based on calendar year 2019, the purchase price represents an adjusted EBITDA multiple of approximately 11 times, or approximately 8 times pro forma for synergies. Huntsman Corporation is a publicly traded global manufacturer and marketer of differentiated and specialty chemicals with 2019 revenues of approximately $7 billion. Our chemical products number in the thousands and are sold worldwide to manufacturers serving a broad and diverse range of consumer and industrial end markets. We operate more than 70 manufacturing, R&D and operations facilities in approximately 30 countries and employ approximately 9,000 associates within our four distinct business divisions. Certain information in this release constitutes forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. These statements are based on management's current beliefs and expectations. The forward-looking statements in this release are subject to uncertainty and changes in circumstances and involve risks and uncertainties that may affect the company's operations, markets, products, services, prices and other factors as discussed under the caption "Risk Factors" in the Huntsman companies' filings with the U.S. Securities and Exchange Commission. Significant risks and uncertainties may relate to, but are not limited to, volatile global economic conditions, cyclical and volatile product markets, disruptions in production at manufacturing facilities, reorganization or restructuring of Huntsman's operations, including any delay of, or other negative developments affecting the ability to implement cost reductions, timing of proposed transactions, and manufacturing optimization improvements in Huntsman businesses and realize anticipated cost savings, ability to achieve projected synergies, and other financial, economic, competitive, environmental, political, legal, regulatory and technological factors. The company assumes no obligation to provide revisions to any forward-looking statements should circumstances change, except as otherwise required by applicable laws.

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Raw Materials

Conservation Groups Sue EPA for Failure to Adequately Protect against Oil, Methane Gas Industry

Conservation Groups | January 18, 2021

Two conservation groups have launched a lawsuit to fight the EPA’s “failure to require adequate pollution controls for the oil and methane gas industry” in Chicago and areas of California. The Center for Biological Diversity and the Center for Environmental Health point out that two Canadian provinces require that the oil and methane gas industry install zero emission pneumatic controllers. “There is no reason the EPA cannot adopt this readily available technology,” says Kaya Sugerman with the Center for Environmental Health. The EPA’s guidelines for oil and methane gas production recommend pneumatic controllers that emit volatile organic compounds, when pneumatic controllers that do not emit any of these compounds are in widespread use at production sites and compressor stations in both the US and Canada, the groups argue. “Taking action to increase the use of zero emission controllers has a co-benefit of reducing methane, a dangerous greenhouse gas that is 87 times more damaging for climate change than carbon dioxide,” the groups say. They point out that, according to the EPA’s Greenhouse Gas Inventory, pneumatic controllers are the largest source of methane from the oil industry and the second-largest source of methane from the methane gas industry.

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