Curbing the costs of chemical manufacturing

The search for new drug candidates has led pharmaceutical investigators to explore molecular structures of increasing complexity. This requirement is the result of the growing recognition that structural complexity can correlate to desirable drug candidate attributes, including enhanced target binding selectivity  solubility and clinical success rates  Considering that structurally complex molecules demand longer and more elaborate series of consecutive chemical transformations for preparation, development teams striving to elaborate efficient and sustainable processes for their manufacture face substantial challenges.On page 681 of this issue, Smaligo et al.  present an example of expeditious preparation of complex molecular scaffolds using new chemical technology.

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EOS Project Management

EOS is a global engineering company currently working on worldwide projects in more than 30 different countries.Our headquarter is located in Pamplona (Spain) and we have presence in Madrid, France, Morocco, South Africa, Egypt, USA, Mexico, Chile and Colombia.

OTHER ARTICLES
Chemical Technology

Closing the loop: Real-time measurement of oil in water for process facilities

Article | July 14, 2022

When an oilfield’s reservoir pressure is depleted during primary recovery, additional oil can be recovered by recycling the produced water and injecting it back into the reservoir. Water management is critical for such water and water-alternating-gas (WAG) floods. In its Permian basin operations, Occidental recovers, recycles, and re-injects large volumes of water for its enhanced oil recovery (EOR) operations. With real-time monitoring of oil in water (OiW) delivering reliable and continuous data, Occidental identified a way to optimize the recovery process and is working with NOV to expand the use of OiW monitoring equipment.

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Chemical Management

Developing pre-rig solutions that are greener, safer and more efficient

Article | July 8, 2022

MAY 2021 ///Vol 242 No. 5 FEATURES Developing pre-rig solutions that are greener, safer and more efficient There is an increased focus in the oil and gas sector to look further afield to opportunities presented in deepwater locations. Because of this, finding cost-efficient solutions and overcoming the associated challenges that arise below 1,000 ft will be vital for the success of new activity. Jostein Aleksandersen, Neodrill There is an increased focus in the oil and gas sector to look further afield to opportunities presented in deepwater locations. Because of this, finding cost-efficient solutions and overcoming the associated challenges that arise below 1,000 ft will be vital for the success of new activity. All those currently—and those considering—operating in deepwater fields will have an awareness of the general challenges that are presented at such depths. From considerations relating to vast increases in pressure, to the potential for increased drilling time and days spent offshore, there are several hurdles that follow when operating in what are often challenging well environments. In addition, suitable solutions also must support the industry drive to reduce emissions by offering a more carbon-efficient approach.

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Chemical Technology

Demographics are reshaping petrochemicals trade flows, investment patterns and demand

Article | July 20, 2022

TEN YEARS AGO, fellowblogger Paul Hodgesand Ifirst highlighted the leading rolethat changing demographics would play in reshaping petrochemicals supply and demand. We have been emphasising the importance of demographics ever since. Demographics have, of course, always been a critical shaper of economies throughout human history. But during the last 70 years, there have been such major changes in demographics that the study of demographics must be at the very heart of your company’s strategy. The Babyboomer generation in the West led to a surge in demand as the rapid increase in babies born in the 1950s and early 1960s joined the workforce from the 1970s onwards. This helps explain high levels of inflation during that decade because too much demand was chasing too little supply. Another driver of inflation was the Middle East embargos against oil exports to the West because of the West’s support for Israel. Then came the 1990s and first the integration of Eastern Europe into the global economy. This helped dampen inflationary pressures because of the plentiful supply of workers in the east willing to work for low wages in export-focused factories. This reduced the cost of finished goods in the West. Next came Deng Xiaoping’s critically important“southern tour”in the early 1990s and China’s gradual integration into the global economy. China increasingly leveraged its very youthful population to again make cheap goods to export to the West. Hundreds of millions of young people were willing to migrate from the countryside to China’s coastal cities to work in export-focused manufacturing plants. The world began to talk about the “China price” and how it was further depressing global inflation.

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Science and Research

More data show how far we still have to go to solve the climate and plastic waste crises

Article | June 27, 2021

SEE THE END section of this blog post for a dystopian version of our environmental future. In a follow-up post – which I will publish on Thursday, 1 July – I will offer some suggestions about how we can avoid an outcome that nobody of course wants.Both posts are meant to be provocative, challenging and controversial because only through debate, and sometimes outright argument, will we get to the answers. If you disagree after either or both posts have been published, great, that would be good. In fact, I would love to hear from you whatever your views at john.richardson@icis.com. The petrochemicals industry can do this; we can fix this if we create the right forums for ideas and then solutions. Let me provide the background first. Let me start by examining developments in the refinery industry and the implications for petrochemicals as important background. Then I will look at a sample of ICIS petrochemicals demand growth forecasts for 2020-2040. I will conclude by providing the bleakest of bleak outcomes for the world in 2025

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EOS Project Management

EOS is a global engineering company currently working on worldwide projects in more than 30 different countries.Our headquarter is located in Pamplona (Spain) and we have presence in Madrid, France, Morocco, South Africa, Egypt, USA, Mexico, Chile and Colombia.

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Chemical Technology

With the Acquisition of Agiplast, Arkema Strengthens Its Commitment to the Circular Economy

ARKEMA | May 25, 2021

With the planned acquisition of Agiplast, a leader in the regeneration of high-performance polymers, especially specialty polyamides, and fluoropolymers, Arkema is going to be ready to offer a full service to customers in terms of materials circularity, addressing growing market expectations during this field. This project, which contributes to the sustainable development of the polymer industry, is perfectly in line with Arkema’s sustainable growth strategy. Arkema plans to accumulate Agiplast, a company specialized in the regeneration of high-performance polymers, and its historical partner in recycling operations. the company, with annual sales of around €15 million, operates a plant in Italy and has 32 employees. Agiplast’s strong know-how in mechanical recycling technologies will enable Arkema to supply top-quality recycled polymers to its customers. In October 2019, Arkema, the world leader in bio-based high-performance polymers, had already launched Virtucycle®, an ambitious program with Agiplast aimed toward developing loops for the gathering and regeneration of high-performance polymers while minimizing CO2 emissions. With this acquisition, Arkema is going to be the primary fully integrated high-performance polymer manufacturer offering both bio-based and recycled materials to deal with the challenges of resource scarcity and end-of-life products. This bolt-on acquisition is thus in line with Arkema’s CSR and sustainable growth strategy, and especially the transition to a circular economy. The deal is expected to close in June 2021. About ARKEMA Building on its unique set of experience in materials science, Arkema offers a portfolio of first-class technologies to address the ever-growing demand for new and sustainable materials. With the ambition to become 2024 a pure player in Specialty Materials, the Group is structured into 3 complementary, resilient, and highly innovative segments dedicated to Specialty Materials -Adhesive solutions, Advanced Materials, and Coating Solutions- accounting for a few 82% of Group sales, and a well-positioned and competitive Intermediates segments. Arkema offers cutting-edge technological solutions to satisfy the challenges of, among other things, new energies, access to water, recycling, urbanization, and mobility and fosters a permanent dialogue with all its stakeholders. The Group reported sales of around €8 billion in 2020 and operates in some 55 countries with 20,600 employees worldwide

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Chemical Management

Huntsman Completes the Acquisition of Gabriel Performance Products, Further Expanding its Specialty Chemicals Portfolio

Huntsman | January 20, 2021

Huntsman Corporation (NYSE: HUN) today announced it completed the acquisition of Gabriel Performance Products (Gabriel), a North American specialty chemical manufacturer of specialty additives and epoxy curing agents for the coatings, adhesives, sealants and composite end-markets, from Audax Private Equity. Huntsman paid $250 million, subject to customary closing adjustments, in an all-cash transaction funded from available liquidity. Gabriel had 2019 revenues of approximately $106 million with three manufacturing facilities located in Ashtabula, Ohio, Harrison City, Pennsylvania and Rock Hill, South Carolina. Based on calendar year 2019, the purchase price represents an adjusted EBITDA multiple of approximately 11 times, or approximately 8 times pro forma for synergies. Huntsman Corporation is a publicly traded global manufacturer and marketer of differentiated and specialty chemicals with 2019 revenues of approximately $7 billion. Our chemical products number in the thousands and are sold worldwide to manufacturers serving a broad and diverse range of consumer and industrial end markets. We operate more than 70 manufacturing, R&D and operations facilities in approximately 30 countries and employ approximately 9,000 associates within our four distinct business divisions. Certain information in this release constitutes forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. These statements are based on management's current beliefs and expectations. The forward-looking statements in this release are subject to uncertainty and changes in circumstances and involve risks and uncertainties that may affect the company's operations, markets, products, services, prices and other factors as discussed under the caption "Risk Factors" in the Huntsman companies' filings with the U.S. Securities and Exchange Commission. Significant risks and uncertainties may relate to, but are not limited to, volatile global economic conditions, cyclical and volatile product markets, disruptions in production at manufacturing facilities, reorganization or restructuring of Huntsman's operations, including any delay of, or other negative developments affecting the ability to implement cost reductions, timing of proposed transactions, and manufacturing optimization improvements in Huntsman businesses and realize anticipated cost savings, ability to achieve projected synergies, and other financial, economic, competitive, environmental, political, legal, regulatory and technological factors. The company assumes no obligation to provide revisions to any forward-looking statements should circumstances change, except as otherwise required by applicable laws.

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Raw Materials

Conservation Groups Sue EPA for Failure to Adequately Protect against Oil, Methane Gas Industry

Conservation Groups | January 18, 2021

Two conservation groups have launched a lawsuit to fight the EPA’s “failure to require adequate pollution controls for the oil and methane gas industry” in Chicago and areas of California. The Center for Biological Diversity and the Center for Environmental Health point out that two Canadian provinces require that the oil and methane gas industry install zero emission pneumatic controllers. “There is no reason the EPA cannot adopt this readily available technology,” says Kaya Sugerman with the Center for Environmental Health. The EPA’s guidelines for oil and methane gas production recommend pneumatic controllers that emit volatile organic compounds, when pneumatic controllers that do not emit any of these compounds are in widespread use at production sites and compressor stations in both the US and Canada, the groups argue. “Taking action to increase the use of zero emission controllers has a co-benefit of reducing methane, a dangerous greenhouse gas that is 87 times more damaging for climate change than carbon dioxide,” the groups say. They point out that, according to the EPA’s Greenhouse Gas Inventory, pneumatic controllers are the largest source of methane from the oil industry and the second-largest source of methane from the methane gas industry.

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Chemical Technology

With the Acquisition of Agiplast, Arkema Strengthens Its Commitment to the Circular Economy

ARKEMA | May 25, 2021

With the planned acquisition of Agiplast, a leader in the regeneration of high-performance polymers, especially specialty polyamides, and fluoropolymers, Arkema is going to be ready to offer a full service to customers in terms of materials circularity, addressing growing market expectations during this field. This project, which contributes to the sustainable development of the polymer industry, is perfectly in line with Arkema’s sustainable growth strategy. Arkema plans to accumulate Agiplast, a company specialized in the regeneration of high-performance polymers, and its historical partner in recycling operations. the company, with annual sales of around €15 million, operates a plant in Italy and has 32 employees. Agiplast’s strong know-how in mechanical recycling technologies will enable Arkema to supply top-quality recycled polymers to its customers. In October 2019, Arkema, the world leader in bio-based high-performance polymers, had already launched Virtucycle®, an ambitious program with Agiplast aimed toward developing loops for the gathering and regeneration of high-performance polymers while minimizing CO2 emissions. With this acquisition, Arkema is going to be the primary fully integrated high-performance polymer manufacturer offering both bio-based and recycled materials to deal with the challenges of resource scarcity and end-of-life products. This bolt-on acquisition is thus in line with Arkema’s CSR and sustainable growth strategy, and especially the transition to a circular economy. The deal is expected to close in June 2021. About ARKEMA Building on its unique set of experience in materials science, Arkema offers a portfolio of first-class technologies to address the ever-growing demand for new and sustainable materials. With the ambition to become 2024 a pure player in Specialty Materials, the Group is structured into 3 complementary, resilient, and highly innovative segments dedicated to Specialty Materials -Adhesive solutions, Advanced Materials, and Coating Solutions- accounting for a few 82% of Group sales, and a well-positioned and competitive Intermediates segments. Arkema offers cutting-edge technological solutions to satisfy the challenges of, among other things, new energies, access to water, recycling, urbanization, and mobility and fosters a permanent dialogue with all its stakeholders. The Group reported sales of around €8 billion in 2020 and operates in some 55 countries with 20,600 employees worldwide

Read More

Chemical Management

Huntsman Completes the Acquisition of Gabriel Performance Products, Further Expanding its Specialty Chemicals Portfolio

Huntsman | January 20, 2021

Huntsman Corporation (NYSE: HUN) today announced it completed the acquisition of Gabriel Performance Products (Gabriel), a North American specialty chemical manufacturer of specialty additives and epoxy curing agents for the coatings, adhesives, sealants and composite end-markets, from Audax Private Equity. Huntsman paid $250 million, subject to customary closing adjustments, in an all-cash transaction funded from available liquidity. Gabriel had 2019 revenues of approximately $106 million with three manufacturing facilities located in Ashtabula, Ohio, Harrison City, Pennsylvania and Rock Hill, South Carolina. Based on calendar year 2019, the purchase price represents an adjusted EBITDA multiple of approximately 11 times, or approximately 8 times pro forma for synergies. Huntsman Corporation is a publicly traded global manufacturer and marketer of differentiated and specialty chemicals with 2019 revenues of approximately $7 billion. Our chemical products number in the thousands and are sold worldwide to manufacturers serving a broad and diverse range of consumer and industrial end markets. We operate more than 70 manufacturing, R&D and operations facilities in approximately 30 countries and employ approximately 9,000 associates within our four distinct business divisions. Certain information in this release constitutes forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. These statements are based on management's current beliefs and expectations. The forward-looking statements in this release are subject to uncertainty and changes in circumstances and involve risks and uncertainties that may affect the company's operations, markets, products, services, prices and other factors as discussed under the caption "Risk Factors" in the Huntsman companies' filings with the U.S. Securities and Exchange Commission. Significant risks and uncertainties may relate to, but are not limited to, volatile global economic conditions, cyclical and volatile product markets, disruptions in production at manufacturing facilities, reorganization or restructuring of Huntsman's operations, including any delay of, or other negative developments affecting the ability to implement cost reductions, timing of proposed transactions, and manufacturing optimization improvements in Huntsman businesses and realize anticipated cost savings, ability to achieve projected synergies, and other financial, economic, competitive, environmental, political, legal, regulatory and technological factors. The company assumes no obligation to provide revisions to any forward-looking statements should circumstances change, except as otherwise required by applicable laws.

Read More

Raw Materials

Conservation Groups Sue EPA for Failure to Adequately Protect against Oil, Methane Gas Industry

Conservation Groups | January 18, 2021

Two conservation groups have launched a lawsuit to fight the EPA’s “failure to require adequate pollution controls for the oil and methane gas industry” in Chicago and areas of California. The Center for Biological Diversity and the Center for Environmental Health point out that two Canadian provinces require that the oil and methane gas industry install zero emission pneumatic controllers. “There is no reason the EPA cannot adopt this readily available technology,” says Kaya Sugerman with the Center for Environmental Health. The EPA’s guidelines for oil and methane gas production recommend pneumatic controllers that emit volatile organic compounds, when pneumatic controllers that do not emit any of these compounds are in widespread use at production sites and compressor stations in both the US and Canada, the groups argue. “Taking action to increase the use of zero emission controllers has a co-benefit of reducing methane, a dangerous greenhouse gas that is 87 times more damaging for climate change than carbon dioxide,” the groups say. They point out that, according to the EPA’s Greenhouse Gas Inventory, pneumatic controllers are the largest source of methane from the oil industry and the second-largest source of methane from the methane gas industry.

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