Chemours Debt, Legal Overhang Should Price It Closer To $14

December 29, 2016 | 137 views

The lawsuit alleges that DuPont's Chambers Works chemical manufacturing plant released more than 100M pounds of toxic chemicals into the town's soil and groundwater, affecting residential areas as far as two miles away, according to the suit filed on behalf of Carneys Point in Superior Court last week.

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Unique Rubber Technologies

A Unique, é a uma das maiores fabricantes de produtos para recapagem e compostos de borracha da América Latina. Na empresa são fabricadas diferentes marcas de produtos para reforma de pneus presentes no mercado sul-americano e os melhores compostos de borracha para indústrias de variados segmentos.

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CHEMICAL MANAGEMENT

Organic Catalyst Boasts Big Benefits

Article | June 13, 2021

An enzyme-mimicking catalyst opens a new route to important organic molecules such as glycolic acid and amino acids from pyruvate, report researchers in Japan. Moreover, the new catalyst is cheaper, more stable, safer and more environmentally friendly than conventional metal catalysts used in industry, they note, adding that it also displays the high enantioselectivity required by the pharmaceutical industry. “On top of these advantages, our newly developed organic catalyst system also promotes reactions using pyruvate that aren’t easily achievable using metal catalysts,” says Santanu Mondal, a PhD candidate in the chemistry and chemical bioengineering unit at Okinawa Institute of Science and Technology (OIST) Graduate University, Okinawa, Japan, and lead author of a study recently published in Organic Letters. “Organic catalysts, in particular, are set to revolutionize the industry and make chemistry more sustainable,” he stresses. The researchers use an acid and an amine mixture to force the pyruvate to act as an electron donor rather than its usual role as an electron receiver (Figure 1). Effectively mimicking how enzymes work, the amine binds to the pyruvate to make an intermediate molecule. The organic acid then covers up part of the intermediate molecule while leaving another part that can donate electrons free to react to form a new product. Currently, the organic catalyst system only works when reacting pyruvate with a specific class of organic molecule called cyclic imines. So, the researchers now are looking to develop a more-universal catalyst, i.e., one that can speed up reactions between pyruvate and a broad range of organic molecules. The challenge here is to try to make the electron-donating intermediate stage of pyruvate react with other functional groups such as aldehydes and ketones. However, different catalysts create different intermediates, all with different properties. For example, the enamine intermediate created by the researchers’ new reaction only reacts with cyclic imines. Their hypothesis, currently being investigated, is that creation of other intermediates such as an enolate, if possible, would achieve a broader pyruvate reactivity. In terms of cost, the researchers note that a palladium catalyst used in similar reactions is 25 times more expensive than their organic acid — which also is made from eco-friendly quinine. In addition, they believe scale-up of the process for industrial use definitely is possible. However, the researchers caution that the current amine-to-acid-catalyst loading ratio of 1:2 probably would need to be optimized for better results at a larger scale.

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CHEMICAL MANAGEMENT

Transporting biological and chemical materials - what you need to know

Article | July 13, 2021

The landscape of biological and chemical logistics has changed rapidly - as have the regulatory frameworks around it. What has not necessarily kept pace is the end-user understanding of the nature of these logistical processes, their opportunities and their constraints. Twenty years ago, the transmission of biological and chemical materials was limited to a small range of organisations: usually national and international research companies, hospitals, major university departments, police and military departments with forensic responsibilities.

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CHEMICAL MANAGEMENT

Setting record straight on testing harm in chemicals

Article | June 15, 2021

The modern world is built on chemicals, be it the medicines we use, or cleaning fluids, crop protection products, or the raw materials for everything from laptops and mobile phones to clothes and furniture. Across all, we have created an entire modern society with chemicals, and, as a result, constantly stretched the size of the world population we can feed, clothe and shelter. Yet, balancing all the gains from the modern chemistry around us against any negative environmental and human impact has been a rising concern, making for ever greater focus on testing and on risk assessment.

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Why chemical characterization is the best way to assess patient risk

Article | February 11, 2020

Everyone is very familiar with the phrase when buying a house: All that really matters are three things - location, location, and location. This same principle applies to extractables and leachables chemistry analysis – the three things that truly matter are identification, identification, and identification. The greatest growth in the past ten years in demonstrating the safety of medical devices and container closure systems for drugs has been using analytical chemistry to determine what chemicals can leach from the device and what the patient is exposed to during its intended use.

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Unique Rubber Technologies

A Unique, é a uma das maiores fabricantes de produtos para recapagem e compostos de borracha da América Latina. Na empresa são fabricadas diferentes marcas de produtos para reforma de pneus presentes no mercado sul-americano e os melhores compostos de borracha para indústrias de variados segmentos.

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US, Canada outline plans to align hazcom standards

Chemical Watch | March 11, 2020

Regulators from the US and Canada have laid out plans to coordinate efforts on workplace hazard communication standards as the two countries implement updates to the UN's Globally Harmonized System of classification and labelling of chemicals (GHS). According to the US-Canada Regulatory Cooperation Council (RCC) 2019-20 workplan, released this week, the council expects to roll out joint guidance on the implementation of GHS and interpreting requirements for safety data sheets (SDSs) and communicating product hazards across the two jurisdictions. Another primary goal, highlighted in the RCC workplan, is to have "one label and one SDS" that is acceptable in both countries. US and Canadian regulators also will continue to work together to push for a common position on the GHS at future UN meetings and plan to hold a stakeholder meeting this summer.

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Protecting people from chemical hazards — another EPA failure in the making

TheHill | November 25, 2019

Most Americans assume that the chemicals in the consumer products we buy, such as that long list of unpronounceable ingredients in your bathroom cleaner or laundry detergent, have been tested and found safe for people and the environment. The truth is, not so much. And Trump’s Environmental Protection Agency (EPA) is missing an important opportunity to make those products safer. For decades, efforts to ensure chemical safety were stymied by an ineffective regulatory regime: the Toxic Substances Control Act (TSCA) of 1976, which regulated household and industrial compounds, was widely regarded as toothless. During my 20-plus year career at EPA, I served as a senior manager in the agency’s toxics program from 1987 to 1989. The weakness of the original TSCA was a key factor in my decision to leave that position.

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Tiny gels sop up intestinal toxins

phys.org | March 20, 2018

Bacterial infections that target the intestine can cause conditions that range from uncomfortable to deadly. While it's easy to blame the bacteria, it's actually the toxins the bacteria produce that trigger inflammation, diarrhea, fever and cramps. Treatment strategies typically include indiscriminate antibiotics that slaughter health-promoting gut bacteria along with disease-causing microbes. Researchers now report the development of a microgel scavenger that targets toxins instead of bacteria. The researchers will present their work today at the 255th National Meeting & Exposition of the American Chemical Society (ACS)."We want to develop a new therapy that is based on scavenging the toxins rather than killing both the good and bad bacteria," says Alexander Kuehne, Ph.D. "This way inflammation can be reduced while supporting the natural intestinal flora and holding the bad bacteria at bay."About three decades ago, Kuehne says, scientists developed a particle that used electronic charge to bind toxins in the intestine. It made it to the clinical testing stage, he says, but had too many non-specific targets for further development. This idea was the basis, though, for Kuehne's team's current project.

Read More

US, Canada outline plans to align hazcom standards

Chemical Watch | March 11, 2020

Regulators from the US and Canada have laid out plans to coordinate efforts on workplace hazard communication standards as the two countries implement updates to the UN's Globally Harmonized System of classification and labelling of chemicals (GHS). According to the US-Canada Regulatory Cooperation Council (RCC) 2019-20 workplan, released this week, the council expects to roll out joint guidance on the implementation of GHS and interpreting requirements for safety data sheets (SDSs) and communicating product hazards across the two jurisdictions. Another primary goal, highlighted in the RCC workplan, is to have "one label and one SDS" that is acceptable in both countries. US and Canadian regulators also will continue to work together to push for a common position on the GHS at future UN meetings and plan to hold a stakeholder meeting this summer.

Read More

Protecting people from chemical hazards — another EPA failure in the making

TheHill | November 25, 2019

Most Americans assume that the chemicals in the consumer products we buy, such as that long list of unpronounceable ingredients in your bathroom cleaner or laundry detergent, have been tested and found safe for people and the environment. The truth is, not so much. And Trump’s Environmental Protection Agency (EPA) is missing an important opportunity to make those products safer. For decades, efforts to ensure chemical safety were stymied by an ineffective regulatory regime: the Toxic Substances Control Act (TSCA) of 1976, which regulated household and industrial compounds, was widely regarded as toothless. During my 20-plus year career at EPA, I served as a senior manager in the agency’s toxics program from 1987 to 1989. The weakness of the original TSCA was a key factor in my decision to leave that position.

Read More

Tiny gels sop up intestinal toxins

phys.org | March 20, 2018

Bacterial infections that target the intestine can cause conditions that range from uncomfortable to deadly. While it's easy to blame the bacteria, it's actually the toxins the bacteria produce that trigger inflammation, diarrhea, fever and cramps. Treatment strategies typically include indiscriminate antibiotics that slaughter health-promoting gut bacteria along with disease-causing microbes. Researchers now report the development of a microgel scavenger that targets toxins instead of bacteria. The researchers will present their work today at the 255th National Meeting & Exposition of the American Chemical Society (ACS)."We want to develop a new therapy that is based on scavenging the toxins rather than killing both the good and bad bacteria," says Alexander Kuehne, Ph.D. "This way inflammation can be reduced while supporting the natural intestinal flora and holding the bad bacteria at bay."About three decades ago, Kuehne says, scientists developed a particle that used electronic charge to bind toxins in the intestine. It made it to the clinical testing stage, he says, but had too many non-specific targets for further development. This idea was the basis, though, for Kuehne's team's current project.

Read More

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