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Spotlight

Spark Therapeutics, Inc.

We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our mission is seemingly impossible to others, but not to us: Challenge the inevitability of genetic disease by discovering, developing and delivering treatments in ways unimaginable – until now. We have doubled in size every year since our founding, bringing in a wide range of expertise to build a fully integrated gene therapy company focused on inherited retinal diseases (IRDs), neurodegenerative diseases, as well as diseases that can be addressed by targeting the liver, such as hemophilia. We are seeking talented individuals with diverse experiences, abilities and interests who have the curiosity, courage and drive to reimagine a new health care paradigm.

OTHER ARTICLES
Chemical Management

Global polyethylene demand boom likely, increasing the sustainability challenge

Article | July 8, 2022

IT FEELS LIKE several lifetimes ago. If you recall, way back in November-December 2019 Asian variable cost integrated naphtha-based polyethylene (PE) margins turned negative because of the increase in US capacity. Then in January the following year, deep Asian and Middle East operating rate cuts returned some order to the market. Then, bang, as we all know, the pandemic arrived and turned everything on its head. The pandemic has, in my view, accentuated trends that were already well underway. I believe this means that the supply-driven downturn that started in late 2019 will not return.Long before coronavirus upended everyone’s lives, PE demand was becoming increasingly divorced from GDP growth because of the shifting nature of end-use demand. Booming internet sales was, I believe, a major factor behind the split between the growth of the overall economies in the developed world plus China and PE demand.The average product bought online is dropped 17 times because of the large number of people involved in the logistics chain, according to Forbes. This had led to a surge in demand for protective packaging made not from PE and other polymers such as polypropylene, expandable polystyrene and PET films (I will look at their demand growth prospects in later posts).Despite sustainability pressures, the scale of demand for stuff bought online translated to a lot more consumption of virgin polymers.

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Chemical Technology

Reimagining the Workforce with Anglo American

Article | August 8, 2022

“At Anglo-American, we’re really focused on finding the best ways to attract the most talented people in the industry and effectively equipping our existing workforce based on what they need today and what the future will mean for their careers. We’re also committed to providing learning opportunities that lead to growth and development in the communities in which we operate. Our people are a strategic advantage. We want to ensure that continues to be the case as the mining industry evolves and faces more disruption.

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Chemical Technology

IoT in Chemical market trends you Can’t miss in 2020: Here’s What Will Happen in the near future?

Article | July 14, 2022

Global IoT in Chemical market research report provides the newest industry data and industry future trends. It allows you to identify the products and end users driving Revenue growth and profitability. The IoT in Chemical industry report lists the leading competitors and provides the game-changing strategic analysis of the key factors driving the market. The report includes the forecasts by 2020-2028, analysis by 2014-2019, and discussion of important industry trends, market size, market share predictions and profiles of the top IoT in Chemical industry players.

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Chemical Technology

Organic Catalyst Boasts Big Benefits

Article | June 6, 2022

An enzyme-mimicking catalyst opens a new route to important organic molecules such as glycolic acid and amino acids from pyruvate, report researchers in Japan. Moreover, the new catalyst is cheaper, more stable, safer and more environmentally friendly than conventional metal catalysts used in industry, they note, adding that it also displays the high enantioselectivity required by the pharmaceutical industry. “On top of these advantages, our newly developed organic catalyst system also promotes reactions using pyruvate that aren’t easily achievable using metal catalysts,” says Santanu Mondal, a PhD candidate in the chemistry and chemical bioengineering unit at Okinawa Institute of Science and Technology (OIST) Graduate University, Okinawa, Japan, and lead author of a study recently published in Organic Letters. “Organic catalysts, in particular, are set to revolutionize the industry and make chemistry more sustainable,” he stresses. The researchers use an acid and an amine mixture to force the pyruvate to act as an electron donor rather than its usual role as an electron receiver (Figure 1). Effectively mimicking how enzymes work, the amine binds to the pyruvate to make an intermediate molecule. The organic acid then covers up part of the intermediate molecule while leaving another part that can donate electrons free to react to form a new product. Currently, the organic catalyst system only works when reacting pyruvate with a specific class of organic molecule called cyclic imines. So, the researchers now are looking to develop a more-universal catalyst, i.e., one that can speed up reactions between pyruvate and a broad range of organic molecules. The challenge here is to try to make the electron-donating intermediate stage of pyruvate react with other functional groups such as aldehydes and ketones. However, different catalysts create different intermediates, all with different properties. For example, the enamine intermediate created by the researchers’ new reaction only reacts with cyclic imines. Their hypothesis, currently being investigated, is that creation of other intermediates such as an enolate, if possible, would achieve a broader pyruvate reactivity. In terms of cost, the researchers note that a palladium catalyst used in similar reactions is 25 times more expensive than their organic acid — which also is made from eco-friendly quinine. In addition, they believe scale-up of the process for industrial use definitely is possible. However, the researchers caution that the current amine-to-acid-catalyst loading ratio of 1:2 probably would need to be optimized for better results at a larger scale.

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Spotlight

Spark Therapeutics, Inc.

We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our mission is seemingly impossible to others, but not to us: Challenge the inevitability of genetic disease by discovering, developing and delivering treatments in ways unimaginable – until now. We have doubled in size every year since our founding, bringing in a wide range of expertise to build a fully integrated gene therapy company focused on inherited retinal diseases (IRDs), neurodegenerative diseases, as well as diseases that can be addressed by targeting the liver, such as hemophilia. We are seeking talented individuals with diverse experiences, abilities and interests who have the curiosity, courage and drive to reimagine a new health care paradigm.

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Chemical Management

Huntsman Completes the Acquisition of Gabriel Performance Products, Further Expanding its Specialty Chemicals Portfolio

Huntsman | January 20, 2021

Huntsman Corporation (NYSE: HUN) today announced it completed the acquisition of Gabriel Performance Products (Gabriel), a North American specialty chemical manufacturer of specialty additives and epoxy curing agents for the coatings, adhesives, sealants and composite end-markets, from Audax Private Equity. Huntsman paid $250 million, subject to customary closing adjustments, in an all-cash transaction funded from available liquidity. Gabriel had 2019 revenues of approximately $106 million with three manufacturing facilities located in Ashtabula, Ohio, Harrison City, Pennsylvania and Rock Hill, South Carolina. Based on calendar year 2019, the purchase price represents an adjusted EBITDA multiple of approximately 11 times, or approximately 8 times pro forma for synergies. Huntsman Corporation is a publicly traded global manufacturer and marketer of differentiated and specialty chemicals with 2019 revenues of approximately $7 billion. Our chemical products number in the thousands and are sold worldwide to manufacturers serving a broad and diverse range of consumer and industrial end markets. We operate more than 70 manufacturing, R&D and operations facilities in approximately 30 countries and employ approximately 9,000 associates within our four distinct business divisions. Certain information in this release constitutes forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. These statements are based on management's current beliefs and expectations. The forward-looking statements in this release are subject to uncertainty and changes in circumstances and involve risks and uncertainties that may affect the company's operations, markets, products, services, prices and other factors as discussed under the caption "Risk Factors" in the Huntsman companies' filings with the U.S. Securities and Exchange Commission. Significant risks and uncertainties may relate to, but are not limited to, volatile global economic conditions, cyclical and volatile product markets, disruptions in production at manufacturing facilities, reorganization or restructuring of Huntsman's operations, including any delay of, or other negative developments affecting the ability to implement cost reductions, timing of proposed transactions, and manufacturing optimization improvements in Huntsman businesses and realize anticipated cost savings, ability to achieve projected synergies, and other financial, economic, competitive, environmental, political, legal, regulatory and technological factors. The company assumes no obligation to provide revisions to any forward-looking statements should circumstances change, except as otherwise required by applicable laws.

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Raw Materials

Conservation Groups Sue EPA for Failure to Adequately Protect against Oil, Methane Gas Industry

Conservation Groups | January 18, 2021

Two conservation groups have launched a lawsuit to fight the EPA’s “failure to require adequate pollution controls for the oil and methane gas industry” in Chicago and areas of California. The Center for Biological Diversity and the Center for Environmental Health point out that two Canadian provinces require that the oil and methane gas industry install zero emission pneumatic controllers. “There is no reason the EPA cannot adopt this readily available technology,” says Kaya Sugerman with the Center for Environmental Health. The EPA’s guidelines for oil and methane gas production recommend pneumatic controllers that emit volatile organic compounds, when pneumatic controllers that do not emit any of these compounds are in widespread use at production sites and compressor stations in both the US and Canada, the groups argue. “Taking action to increase the use of zero emission controllers has a co-benefit of reducing methane, a dangerous greenhouse gas that is 87 times more damaging for climate change than carbon dioxide,” the groups say. They point out that, according to the EPA’s Greenhouse Gas Inventory, pneumatic controllers are the largest source of methane from the oil industry and the second-largest source of methane from the methane gas industry.

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Raw Materials

Honeywell technology helps Hengli Petrochemical reduce nitrogen oxide and carbon emissions

Honeywell | January 14, 2021

Hengli Petrochemical Co. Ltd has effectively utilized Callidus burner innovation from Honeywell UOP to limit nitrogen oxide (NOX) and carbon monoxide (CO) discharges in China, and decrease the effect of these outflows while guaranteeing protected and stable tasks. Hengli chose Callidus progressed flares and low-NOX burner innovation in 2017 to follow ecological guidelines and improve energy productivity and operational wellbeing at its treatment facility and petrochemicals complex in Dalian, Liaoning Province. Furnished with imaginative low fire mode (LFM) innovation, Callidus burners decreased Hengli's emanations, improving air quality and assisting with killing reasons for corrosive downpour. At the point when heater temperatures are beneath 650°C, the NOX burner produces more significant levels of CO. However, by utilizing the LFM innovation, the Callidus burners kept outflows at ideal levels – with NOX and CO each under 50 mg/Nm3. This assisted Hengli with taking care of an industry issue of limiting both NOX and CO outflows to diminish natural effect, while guaranteeing protected and stable activities. "We chose the Callidus innovation since it's the worldwide pioneer in ignition advances and on the grounds that it was the first in China to address the CO outflow issue in a NOX burner," said Liang Peng, Static Equipment Director, Hengli Petrochemical. "Callidus burners likewise can be supplanted without requiring a closure of the heater and different tasks." "Our involvement in these innovations around the world assists clients with preferring Hengli create monetary incentive by improving their rate of profitability with ecologically stable items," said Xiang Lei, VP and senior supervisor, Honeywell UOP China. "We're satisfied to work with Hengli to improve its energy effectiveness and operational security."

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Chemical Management

Huntsman Completes the Acquisition of Gabriel Performance Products, Further Expanding its Specialty Chemicals Portfolio

Huntsman | January 20, 2021

Huntsman Corporation (NYSE: HUN) today announced it completed the acquisition of Gabriel Performance Products (Gabriel), a North American specialty chemical manufacturer of specialty additives and epoxy curing agents for the coatings, adhesives, sealants and composite end-markets, from Audax Private Equity. Huntsman paid $250 million, subject to customary closing adjustments, in an all-cash transaction funded from available liquidity. Gabriel had 2019 revenues of approximately $106 million with three manufacturing facilities located in Ashtabula, Ohio, Harrison City, Pennsylvania and Rock Hill, South Carolina. Based on calendar year 2019, the purchase price represents an adjusted EBITDA multiple of approximately 11 times, or approximately 8 times pro forma for synergies. Huntsman Corporation is a publicly traded global manufacturer and marketer of differentiated and specialty chemicals with 2019 revenues of approximately $7 billion. Our chemical products number in the thousands and are sold worldwide to manufacturers serving a broad and diverse range of consumer and industrial end markets. We operate more than 70 manufacturing, R&D and operations facilities in approximately 30 countries and employ approximately 9,000 associates within our four distinct business divisions. Certain information in this release constitutes forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. These statements are based on management's current beliefs and expectations. The forward-looking statements in this release are subject to uncertainty and changes in circumstances and involve risks and uncertainties that may affect the company's operations, markets, products, services, prices and other factors as discussed under the caption "Risk Factors" in the Huntsman companies' filings with the U.S. Securities and Exchange Commission. Significant risks and uncertainties may relate to, but are not limited to, volatile global economic conditions, cyclical and volatile product markets, disruptions in production at manufacturing facilities, reorganization or restructuring of Huntsman's operations, including any delay of, or other negative developments affecting the ability to implement cost reductions, timing of proposed transactions, and manufacturing optimization improvements in Huntsman businesses and realize anticipated cost savings, ability to achieve projected synergies, and other financial, economic, competitive, environmental, political, legal, regulatory and technological factors. The company assumes no obligation to provide revisions to any forward-looking statements should circumstances change, except as otherwise required by applicable laws.

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Raw Materials

Conservation Groups Sue EPA for Failure to Adequately Protect against Oil, Methane Gas Industry

Conservation Groups | January 18, 2021

Two conservation groups have launched a lawsuit to fight the EPA’s “failure to require adequate pollution controls for the oil and methane gas industry” in Chicago and areas of California. The Center for Biological Diversity and the Center for Environmental Health point out that two Canadian provinces require that the oil and methane gas industry install zero emission pneumatic controllers. “There is no reason the EPA cannot adopt this readily available technology,” says Kaya Sugerman with the Center for Environmental Health. The EPA’s guidelines for oil and methane gas production recommend pneumatic controllers that emit volatile organic compounds, when pneumatic controllers that do not emit any of these compounds are in widespread use at production sites and compressor stations in both the US and Canada, the groups argue. “Taking action to increase the use of zero emission controllers has a co-benefit of reducing methane, a dangerous greenhouse gas that is 87 times more damaging for climate change than carbon dioxide,” the groups say. They point out that, according to the EPA’s Greenhouse Gas Inventory, pneumatic controllers are the largest source of methane from the oil industry and the second-largest source of methane from the methane gas industry.

Read More

Raw Materials

Honeywell technology helps Hengli Petrochemical reduce nitrogen oxide and carbon emissions

Honeywell | January 14, 2021

Hengli Petrochemical Co. Ltd has effectively utilized Callidus burner innovation from Honeywell UOP to limit nitrogen oxide (NOX) and carbon monoxide (CO) discharges in China, and decrease the effect of these outflows while guaranteeing protected and stable tasks. Hengli chose Callidus progressed flares and low-NOX burner innovation in 2017 to follow ecological guidelines and improve energy productivity and operational wellbeing at its treatment facility and petrochemicals complex in Dalian, Liaoning Province. Furnished with imaginative low fire mode (LFM) innovation, Callidus burners decreased Hengli's emanations, improving air quality and assisting with killing reasons for corrosive downpour. At the point when heater temperatures are beneath 650°C, the NOX burner produces more significant levels of CO. However, by utilizing the LFM innovation, the Callidus burners kept outflows at ideal levels – with NOX and CO each under 50 mg/Nm3. This assisted Hengli with taking care of an industry issue of limiting both NOX and CO outflows to diminish natural effect, while guaranteeing protected and stable activities. "We chose the Callidus innovation since it's the worldwide pioneer in ignition advances and on the grounds that it was the first in China to address the CO outflow issue in a NOX burner," said Liang Peng, Static Equipment Director, Hengli Petrochemical. "Callidus burners likewise can be supplanted without requiring a closure of the heater and different tasks." "Our involvement in these innovations around the world assists clients with preferring Hengli create monetary incentive by improving their rate of profitability with ecologically stable items," said Xiang Lei, VP and senior supervisor, Honeywell UOP China. "We're satisfied to work with Hengli to improve its energy effectiveness and operational security."

Read More

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