Chemical Technology
Article | July 20, 2022
An enzyme-mimicking catalyst opens a new route to important organic molecules such as glycolic acid and amino acids from pyruvate, report researchers in Japan. Moreover, the new catalyst is cheaper, more stable, safer and more environmentally friendly than conventional metal catalysts used in industry, they note, adding that it also displays the high enantioselectivity required by the pharmaceutical industry.
“On top of these advantages, our newly developed organic catalyst system also promotes reactions using pyruvate that aren’t easily achievable using metal catalysts,” says Santanu Mondal, a PhD candidate in the chemistry and chemical bioengineering unit at Okinawa Institute of Science and Technology (OIST) Graduate University, Okinawa, Japan, and lead author of a study recently published in Organic Letters.
“Organic catalysts, in particular, are set to revolutionize the industry and make chemistry more sustainable,” he stresses.
The researchers use an acid and an amine mixture to force the pyruvate to act as an electron donor rather than its usual role as an electron receiver (Figure 1).
Effectively mimicking how enzymes work, the amine binds to the pyruvate to make an intermediate molecule. The organic acid then covers up part of the intermediate molecule while leaving another part that can donate electrons free to react to form a new product.
Currently, the organic catalyst system only works when reacting pyruvate with a specific class of organic molecule called cyclic imines.
So, the researchers now are looking to develop a more-universal catalyst, i.e., one that can speed up reactions between pyruvate and a broad range of organic molecules.
The challenge here is to try to make the electron-donating intermediate stage of pyruvate react with other functional groups such as aldehydes and ketones. However, different catalysts create different intermediates, all with different properties. For example, the enamine intermediate created by the researchers’ new reaction only reacts with cyclic imines. Their hypothesis, currently being investigated, is that creation of other intermediates such as an enolate, if possible, would achieve a broader pyruvate reactivity.
In terms of cost, the researchers note that a palladium catalyst used in similar reactions is 25 times more expensive than their organic acid — which also is made from eco-friendly quinine.
In addition, they believe scale-up of the process for industrial use definitely is possible. However, the researchers caution that the current amine-to-acid-catalyst loading ratio of 1:2 probably would need to be optimized for better results at a larger scale.
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Chemical Management
Article | July 8, 2022
Downhole fluid build-up coupled with a drop in reservoir pressure can lead to the rapid decline of gas production rates, and can ultimately result in a well ceasing production. While there are many ways to deliquify a well to maximise production, chemical foamers can be incredibly effective and well worth considering. In this blog post, Kevin Lonie shares some of the benefits of using chemical foamers, and provides insights and advice around how best to use them… “Foamers are a much cheaper option than alternative solutions, such as mechanical lifts, and there is very little risk associated with their usage. If a foamer doesn’t work, it won’t make the well worse - so often we see clients giving them a go before opting for more expensive methods, in the hope that they produce the desired results. And we have seen their success over and over again.”
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Chemical Technology
Article | August 8, 2022
Over the next five to seven years, the chemical sector will place a greater emphasis on sustainability, and digitization will play a significant part in this. Reducing resource use, pollution, energy consumption, and waste are some of its main applications. Additionally, it will increase demand for a circular economy supported by IoT, AI, and other digital technologies.
Some of the systems now in place or being used in the sector include autonomous solutions that enable lower energy usage, dispatching systems for effective logistics and strategies for sustainable power and fuel consumption.
Chemical players making the switch to digital platforms have a chance to triumph if they move swiftly and update their operational models in accordance with a few common success characteristics. In fact, according to our study, making the correct decisions can increase total earnings before interest, taxes, depreciation, and amortization by 3 percent or more (EBITDA).
The Next Step of Operational Excellence
The same level of transformation is available with digital technology for optimal performance, together with success-enabling measures. The same level of corporate participation and realignment will also be necessary for the effective implementation of digital technology.
Finance and telecoms were early leaders in adopting digital technology faster than the chemical sector, which has just recently started to move in more significant numbers toward digitalization.
A circular economy in the sector is also being enabled by the use and evaluation of digital technology. The "Right to Fix" movement is being driven by governments and legislators in Europe and the US, and small and medium-sized businesses in the industry are expected to invest in technology that makes it easier to repair electronic items with the least amount of waste.
On a side note, by enabling the re-use of resources and products throughout the supply chain, digitalization with lean manufacturing (LM) would enable businesses to improve operational excellence and create value, thereby supporting the circular economy goal.
Conclusion
Given its extensive safety and regulatory requirements, the chemical sector has evolved slowly. However, as the global economy changes, some skills will become obsolete and others essential.
The interconnectedness of people, processes, and technology, as well as the requirement for real-time insight at the levels closest to the action, are among the basic principles of Industry 4.0. These values have existed for some time and are an extension of our teams' current operational excellence initiatives.
Digital transformation is not a technology endpoint but rather the following stage in the process and business evolution as the chemicals industry advances continuously.
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Chemical Technology
Article | July 20, 2022
Cybersecurity concerns must be considered in order for the chemical sector to succeed with digital commerce; simply listing your products on an online store and crossing your fingers won't cut it. It is crucial to pick a spouse who is aware of these hazards and has a strong defense in place. It is evident that the sector has massive potential for online sales, but selling chemicals online is different from selling common consumer goods online. Who your consumers are and how you gather and maintain data about them raise severe security and privacy problems.
Chemical company leaders have every right to be concerned about the privacy of their data, given that one cyber attack occurs every 11 seconds. However, they should still go online because there is too much business risk in not taking advantage of the digital opportunity.
Deloitte estimates that the chemical sector alone sold over $27 billion worth of goods online in 2020.
More than half (58%) of chemical purchasers reportedly stated that they would transfer providers if their demands, which include demands for a fantastic digital experience, were not delivered.
The objective is to limit risk and create a secure digital sales environment rather than dismissing e-commerce due to cybersecurity issues.
Setting up the appropriate IT infrastructure: Building for convenience and security is possible thanks to new IT technologies.
Emphasis on confirming identification: Always be aware of who you are dealing with, regardless of whether they came through a digital or physical means.
Offering simple (and safe) reorder alternatives to clients that have been verified.
It's ideal for business owners in the chemical sector who want to test selling online but are concerned about data collecting, security, and privacy for my company and customers.
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